WAP four-disulfide core domain protein 2 (WFDC2)

About WAP four-disulfide core domain protein 2

WAP four-disulfide core domain protein 2 (WFDC2) is a protein from Homo sapiens identified by UniProt accession Q14508, 124 residues long. MolForge cross-references it against 0 known binders and 314 disease associations.

Target properties

Protein name	WAP four-disulfide core domain protein 2
UniProt accession	Q14508
Gene	WFDC2
Organism	Homo sapiens
Length	124 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (314)

Diseases linked to this target (Open Targets).

interstitial lung disease · score 0.11
neoplasm · score 0.11
lung adenocarcinoma · score 0.11
chronic kidney disease · score 0.11
ovarian cancer · score 0.10
renal fibrosis · score 0.10
immature platelet fraction · score 0.09
laryngotracheoesophageal cleft · score 0.09
breast cancer · score 0.09
chronic obstructive pulmonary disease · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14508-F1	alphafold	PREDICTED	82.12	—

Amino-acid sequence (124 residues)

MPACRLGPLA AALLLSLLLF GFTLVSGTGA EKTGVCPELQ ADQNCTQECV SDSECADNLK CCSAGCATFC SLPNDKEGSC PQVNINFPQL GLCRDQCQVD SQCPGQMKCC RNGCGKVSCV TPNF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards