About Factor VII-activating protease
Factor VII-activating protease (HABP2) is a protein
from Homo sapiens identified by UniProt accession
Q14520, 560 residues long.
MolForge cross-references it against 0 known binders and
168 disease associations.
Target properties
| Protein name | Factor VII-activating protease |
|---|
| UniProt accession | Q14520 |
|---|
| Gene | HABP2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 560 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (168)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.49
- eosinophil percentage of leukocytes · score 0.45
- thyroid cancer, nonmedullary, 5 · score 0.41
- familial papillary or follicular thyroid carcinoma · score 0.37
- follicular thyroid carcinoma · score 0.37
- central corneal thickness · score 0.34
- blood protein measurement · score 0.33
- PHF-tau measurement · score 0.30
- Dementia · score 0.29
- amyloid-beta measurement · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14520-F1 | alphafold | PREDICTED | 77.62 | — |
Amino-acid sequence (560 residues)
MFARMSDLHV LLLMALVGKT ACGFSLMSLL ESLDPDWTPD QYDYSYEDYN QEENTSSTLT HAENPDWYYT EDQADPCQPN PCEHGGDCLV HGSTFTCSCL APFSGNKCQK VQNTCKDNPC GRGQCLITQS PPYYRCVCKH PYTGPSCSQV VPVCRPNPCQ NGATCSRHKR RSKFTCACPD QFKGKFCEIG SDDCYVGDGY SYRGKMNRTV NQHACLYWNS HLLLQENYNM FMEDAETHGI GEHNFCRNPD ADEKPWCFIK VTNDKVKWEY CDVSACSAQD VAYPEESPTE PSTKLPGFDS CGKTEIAERK IKRIYGGFKS TAGKHPWQAS LQSSLPLTIS MPQGHFCGGA LIHPCWVLTA AHCTDIKTRH LKVVLGDQDL KKEEFHEQSF RVEKIFKYSH YNERDEIPHN DIALLKLKPV DGHCALESKY VKTVCLPDGS FPSGSECHIS GWGVTETGKG SRQLLDAKVK LIANTLCNSR QLYDHMIDDS MICAGNLQKP GQDTCQGDSG GPLTCEKDGT YYVYGIVSWG LECGKRPGVY TQVTKFLNWI KATIKSESGF
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