Keratin, type I cuticular Ha3-II (KRT33B)

About Keratin, type I cuticular Ha3-II

Keratin, type I cuticular Ha3-II (KRT33B) is a protein from Homo sapiens identified by UniProt accession Q14525, 404 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.

Target properties

Protein name	Keratin, type I cuticular Ha3-II
UniProt accession	Q14525
Gene	KRT33B
Organism	Homo sapiens
Length	404 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (26)

Diseases linked to this target (Open Targets).

glioblastoma multiforme · score 0.19
head and neck squamous cell carcinoma · score 0.18
esophageal cancer · score 0.14
low grade glioma · score 0.11
cryptorchidism · score 0.04
Testicular regression syndrome · score 0.04
isolated congenital hypogonadotropic hypogonadism · score 0.04
renal hypodysplasia/aplasia 3 · score 0.04
46,XY complete gonadal dysgenesis · score 0.04
46,XX ovotesticular disorder of sex development · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14525-F1	alphafold	PREDICTED	79.11	—

Amino-acid sequence (404 residues)

MPYNFCLPSL SCRTSCSSRP CVPPSCHGYT LPGACNIPAN VSNCNWFCEG SFNGSEKETM QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLLC PSYQSYFKTI EELQQKILCS KSENARLVVQ IDNAKLAADD FRTKYQTEQS LRQLVESDIN SLRRILDELT LCRSDLEAQM ESLKEELLSL KQNHEQEVNT LRCQLGDRLN VEVDAAPAVD LNQVLNETRN QYEALVETNR REVEQWFATQ TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRYSLENTL TESEARYSSQ LSQVQSLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE CEINTYRSLL ESEDCKLPSN PCATTNACEK PIGSCVTNPC GPRSRCGPCN TFGY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards