Keratin, type I cuticular Ha2 (KRT32)

About Keratin, type I cuticular Ha2

Keratin, type I cuticular Ha2 (KRT32) is a protein from Homo sapiens identified by UniProt accession Q14532, 448 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.

Target properties

Protein name	Keratin, type I cuticular Ha2
UniProt accession	Q14532
Gene	KRT32
Organism	Homo sapiens
Length	448 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (45)

Diseases linked to this target (Open Targets).

glioblastoma multiforme · score 0.19
head and neck squamous cell carcinoma · score 0.18
ovarian cancer · score 0.18
breast adenocarcinoma · score 0.18
thyroid gland adenocarcinoma · score 0.16
esophageal cancer · score 0.14
hair shape measurement · score 0.09
hemoglobin E-beta-thalassemia syndrome · score 0.05
hemoglobin D disease · score 0.05
familial pityriasis rubra pilaris · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14532-F1	alphafold	PREDICTED	75.22	—

Amino-acid sequence (448 residues)

MTSSCCVTNN LQASLKSCPR PASVCSSGVN CRPELCLGYV CQPMACLPSV CLPTTFRPAS CLSKTYLSSS CQAASGISGS MGPGSWYSEG AFNGNEKETM QFLNDRLASY LTRVRQLEQE NAELESRIQE ASHSQVLTMT PDYQSHFRTI EELQQKILCT KAENARMVVN IDNAKLAADD FRAKYEAELA MRQLVEADIN GLRRILDDLT LCKADLEAQV ESLKEELMCL KKNHEEEVGS LRCQLGDRLN IEVDAAPPVD LTRVLEEMRC QYEAMVEANR RDVEEWFNMQ MEELNQQVAT SSEQLQNYQS DIIDLRRTVN TLEIELQAQH SLRDSLENTL TESEARYSSQ LAQMQCMITN VEAQLAEIRA DLERQNQEYQ VLLDVRARLE GEINTYRSLL ENEDCKLPCN PCSTPSCTTC VPSPCVPRTV CVPRTVGMPC SPCPQGRY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards