Keratin, type II cuticular Hb1 (KRT81)

About Keratin, type II cuticular Hb1

Keratin, type II cuticular Hb1 (KRT81) is a protein from Homo sapiens identified by UniProt accession Q14533, 505 residues long. MolForge cross-references it against 0 known binders and 69 disease associations.

Target properties

Protein name	Keratin, type II cuticular Hb1
UniProt accession	Q14533
Gene	KRT81
Organism	Homo sapiens
Length	505 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (69)

Diseases linked to this target (Open Targets).

monilethrix · score 0.70
head and neck squamous cell carcinoma · score 0.19
prostate adenocarcinoma · score 0.19
glioblastoma multiforme · score 0.18
breast adenocarcinoma · score 0.18
brain volume measurement · score 0.13
neoplasm · score 0.09
triple-negative breast cancer · score 0.08
lung adenocarcinoma · score 0.07
plasma fibronectin deficiency · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14533-F1	alphafold	PREDICTED	71.94	—

Amino-acid sequence (505 residues)

MTCGSGFGGR AFSCISACGP RPGRCCITAA PYRGISCYRG LTGGFGSHSV CGGFRAGSCG RSFGYRSGGV CGPSPPCITT VSVNESLLTP LNLEIDPNAQ CVKQEEKEQI KSLNSRFAAF IDKVRFLEQQ NKLLETKLQF YQNRECCQSN LEPLFEGYIE TLRREAECVE ADSGRLASEL NHVQEVLEGY KKKYEEEVSL RATAENEFVA LKKDVDCAYL RKSDLEANVE ALIQEIDFLR RLYEEEILIL QSHISDTSVV VKLDNSRDLN MDCIIAEIKA QYDDIVTRSR AEAESWYRSK CEEMKATVIR HGETLRRTKE EINELNRMIQ RLTAEVENAK CQNSKLEAAV AQSEQQGEAA LSDARCKLAE LEGALQKAKQ DMACLIREYQ EVMNSKLGLD IEIATYRRLL EGEEQRLCEG IGAVNVCVSS SRGGVVCGDL CVSGSRPVTG SVCSAPCNGN VAVSTGLCAP CGQLNTTCGG GSCGVGSCGI SSLGVGSCGS SCRKC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards