Hepatocyte nuclear factor 4-gamma (HNF4G)

About Hepatocyte nuclear factor 4-gamma

Hepatocyte nuclear factor 4-gamma (HNF4G) is a protein from Homo sapiens identified by UniProt accession Q14541, 408 residues long. MolForge cross-references it against 0 known binders and 105 disease associations.

Target properties

Protein name	Hepatocyte nuclear factor 4-gamma
UniProt accession	Q14541
Gene	HNF4G
Organism	Homo sapiens
Length	408 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (105)

Diseases linked to this target (Open Targets).

urate measurement · score 0.49
breast carcinoma · score 0.48
uric acid measurement · score 0.46
erythrocyte count · score 0.46
hemoglobin measurement · score 0.45
body mass index · score 0.44
hematocrit · score 0.43
serum gamma-glutamyl transferase measurement · score 0.43
neurodegenerative disease · score 0.41
body fat percentage · score 0.39

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14541-F1	alphafold	PREDICTED	80.46	—

Amino-acid sequence (408 residues)

MNTTDNGVNC LCAICGDRAT GKHYGASSCD GCKGFFRRSI RKSHVYSCRF SRQCVVDKDK RNQCRYCRLR KCFRAGMKKE AVQNERDRIS TRRSTFDGSN IPSINTLAQA EVRSRQISVS SPGSSTDINV KKIASIGDVC ESMKQQLLVL VEWAKYIPAF CELPLDDQVA LLRAHAGEHL LLGATKRSMM YKDILLLGNN YVIHRNSCEV EISRVANRVL DELVRPFQEI QIDDNEYACL KAIVFFDPDA KGLSDPVKIK NMRFQVQIGL EDYINDRQYD SRGRFGELLL LLPTLQSITW QMIEQIQFVK LFGMVKIDNL LQEMLLGGAS NDGSHLHHPM HPHLSQDPLT GQTILLGPMS TLVHADQIST PETPLPSPPQ GSGQEQYKIA ANQASVISHQ HLSKQKQL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards