Equilibrative nucleoside transporter 2 (SLC29A2)

About Equilibrative nucleoside transporter 2

Equilibrative nucleoside transporter 2 (SLC29A2) is a protein from Homo sapiens identified by UniProt accession Q14542, 456 residues long. MolForge cross-references it against 0 known binders and 67 disease associations.

Target properties

Protein name	Equilibrative nucleoside transporter 2
UniProt accession	Q14542
Gene	SLC29A2
Organism	Homo sapiens
Length	456 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (67)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.27
handedness · score 0.13
cutaneous melanoma · score 0.12
urate measurement · score 0.07
C-reactive protein measurement · score 0.06
gestational diabetes · score 0.06
serum metabolite measurement · score 0.05
BMI-adjusted waist circumference · score 0.04
BMI-adjusted waist-hip ratio · score 0.04
self reported educational attainment · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14542-F1	alphafold	PREDICTED	84.19	—

Amino-acid sequence (456 residues)

MARGDAPRDS YHLVGISFFI LGLGTLLPWN FFITAIPYFQ ARLAGAGNST ARILSTNHTG PEDAFNFNNW VTLLSQLPLL LFTLLNSFLY QCVPETVRIL GSLLAILLLF ALTAALVKVD MSPGPFFSIT MASVCFINSF SAVLQGSLFG QLGTMPSTYS TLFLSGQGLA GIFAALAMLL SMASGVDAET SALGYFITPC VGILMSIVCY LSLPHLKFAR YYLANKSSQA QAQELETKAE LLQSDENGIP SSPQKVALTL DLDLEKEPES EPDEPQKPGK PSVFTVFQKI WLTALCLVLV FTVTLSVFPA ITAMVTSSTS PGKWSQFFNP ICCFLLFNIM DWLGRSLTSY FLWPDEDSRL LPLLVCLRFL FVPLFMLCHV PQRSRLPILF PQDAYFITFM LLFAVSNGYL VSLTMCLAPR QVLPHEREVA GALMTFFLAL GLSCGASLSF LFKALL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards