Homeobox protein GBX-1 (GBX1)

About Homeobox protein GBX-1

Homeobox protein GBX-1 (GBX1) is a protein from Homo sapiens identified by UniProt accession Q14549, 363 residues long. MolForge cross-references it against 0 known binders and 114 disease associations.

Target properties

Protein name	Homeobox protein GBX-1
UniProt accession	Q14549
Gene	GBX1
Organism	Homo sapiens
Length	363 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (114)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.24
Syndactyly type 2 · score 0.06
autosomal dominant sensory ataxia 1 · score 0.05
autosomal recessive spondylocostal dysostosis · score 0.05
syndactyly type 5 · score 0.05
mesoaxial synostotic syndactyly with phalangeal reduction · score 0.05
spondylometaphyseal dysplasia, A4 type · score 0.05
syndactyly type 4 · score 0.05
Charcot-Marie-Tooth disease type 1A · score 0.05
amyotrophic lateral sclerosis · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14549-F1	alphafold	PREDICTED	59.06	—

Amino-acid sequence (363 residues)

MQRAGGGSAP GGNGGGGGGG PGTAFSIDSL IGPPPPRSGH LLYTGYPMFM PYRPLVLPQA LAPAPLPAGL PPLAPLASFA GRLTNTFCAG LGQAVPSMVA LTTALPSFAE PPDAFYGPQE LAAAAAAAAA TAARNNPEPG GRRPEGGLEA DELLPAREKV AEPPPPPPPH FSETFPSLPA EGKVYSSDEE KLEASAGDPA GSEQEEEGSG GDSEDDGFLD SSAGGPGALL GPKPKLKGSL GTGAEEGAPV TAGVTAPGGK SRRRRTAFTS EQLLELEKEF HCKKYLSLTE RSQIAHALKL SEVQVKIWFQ NRRAKWKRIK AGNVSSRSGE PVRNPKIVVP IPVHVNRFAV RSQHQQMEQG ARP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards