Protein disulfide-isomerase A5 (PDIA5)

About Protein disulfide-isomerase A5

Protein disulfide-isomerase A5 (PDIA5) is a protein from Homo sapiens identified by UniProt accession Q14554, 519 residues long. MolForge cross-references it against 0 known binders and 87 disease associations.

Target properties

Protein name	Protein disulfide-isomerase A5
UniProt accession	Q14554
Gene	PDIA5
Organism	Homo sapiens
Length	519 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (87)

Diseases linked to this target (Open Targets).

platelet count · score 0.49
blood protein measurement · score 0.47
mean platelet volume · score 0.46
platelet component distribution width · score 0.43
platelet crit · score 0.42
fibrinogen measurement · score 0.36
interleukin 17 measurement · score 0.31
myeloid white cell count · score 0.31
cancer · score 0.09
glioblastoma multiforme · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14554-F1	alphafold	PREDICTED	89.22	—

Amino-acid sequence (519 residues)

MARAGPAWLL LAIWVVLPSW LSSAKVSSLI ERISDPKDLK KLLRTRNNVL VLYSKSEVAA ENHLRLLSTV AQAVKGQGTI CWVDCGDAES RKLCKKMKVD LSPKDKKVEL FHYQDGAFHT EYNRAVTFKS IVAFLKDPKG PPLWEEDPGA KDVVHLDSEK DFRRLLKKEE KPLLIMFYAP WCSMCKRMMP HFQKAATQLR GHAVLAGMNV YSSEFENIKE EYSVRGFPTI CYFEKGRFLF QYDNYGSTAE DIVEWLKNPQ PPQPQVPETP WADEGGSVYH LTDEDFDQFV KEHSSVLVMF HAPWCGHCKK MKPEFEKAAE ALHGEADSSG VLAAVDATVN KALAERFHIS EFPTLKYFKN GEKYAVPVLR TKKKFLEWMQ NPEAPPPPEP TWEEQQTSVL HLVGDNFRET LKKKKHTLVM FYAPWCPHCK KVIPHFTATA DAFKDDRKIA CAAVDCVKDK NQDLCQQEAV KGYPTFHYYH YGKFAEKYDS DRTELGFTNY IRALREGDHE RLGKKKEEL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards