About Phosphoribosyl pyrophosphate synthase-associated protein 1
Phosphoribosyl pyrophosphate synthase-associated protein 1 (PRPSAP1) is a protein
from Homo sapiens identified by UniProt accession
Q14558, 356 residues long.
MolForge cross-references it against 0 known binders and
25 disease associations.
Target properties
| Protein name | Phosphoribosyl pyrophosphate synthase-associated protein 1 |
|---|
| UniProt accession | Q14558 |
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| Gene | PRPSAP1 |
|---|
| Organism | Homo sapiens |
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| Length | 356 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (25)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- urate measurement · score 0.36
- reticulocyte count · score 0.22
- reticulocyte measurement · score 0.20
- Immature Reticulocyte Fraction Measurement · score 0.13
- lymphocyte count · score 0.12
- platelet-to-lymphocyte ratio · score 0.10
- mean corpuscular volume · score 0.10
- myeloid white cell count · score 0.09
- uric acid measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14558-F1 | alphafold | PREDICTED | 88.87 | — |
Amino-acid sequence (356 residues)
MNAARTGYRV FSANSTAACT ELAKRITERL GAELGKSVVY QETNGETRVE IKESVRGQDI FIIQTIPRDV NTAVMELLIM AYALKTACAR NIIGVIPYFP YSKQSKMRKR GSIVCKLLAS MLAKAGLTHI ITMDLHQKEI QGFFSFPVDN LRASPFLLQY IQEEIPNYRN AVIVAKSPDA AKRAQSYAER LRLGLAVIHG EAQCTELDMD DGRHSPPMVK NATVHPGLEL PLMMAKEKPP ITVVGDVGGR IAIIVDDIID DVESFVAAAE ILKERGAYKI YVMATHGILS AEAPRLIEES SVDEVVVTNT VPHEVQKLQC PKIKTVDISL ILSEAIRRIH NGESMAYLFR NITVDD
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