About Meiotic recombination protein DMC1/LIM15 homolog
Meiotic recombination protein DMC1/LIM15 homolog (DMC1) is a protein
from Homo sapiens identified by UniProt accession
Q14565, 340 residues long.
MolForge cross-references it against 0 known binders and
177 disease associations.
Target properties
| Protein name | Meiotic recombination protein DMC1/LIM15 homolog |
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| UniProt accession | Q14565 |
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| Gene | DMC1 |
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| Organism | Homo sapiens |
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| Length | 340 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (177)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.44
- mathematical ability · score 0.24
- head and neck squamous cell carcinoma · score 0.23
- breast adenocarcinoma · score 0.22
- lung adenocarcinoma · score 0.18
- high density lipoprotein cholesterol measurement · score 0.16
- partial chromosome Y deletion · score 0.10
- spermatogenic failures 50 · score 0.09
- spermatogenic failure 25 · score 0.09
- spermatogenic failure 59 · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14565-F1 | alphafold | PREDICTED | 90.80 | — |
Amino-acid sequence (340 residues)
MKEDQVVAEE PGFQDEEESL FQDIDLLQKH GINVADIKKL KSVGICTIKG IQMTTRRALC NVKGLSEAKV DKIKEAANKL IEPGFLTAFE YSEKRKMVFH ITTGSQEFDK LLGGGIESMA ITEAFGEFRT GKTQLSHTLC VTAQLPGAGG YPGGKIIFID TENTFRPDRL RDIADRFNVD HDAVLDNVLY ARAYTSEHQM ELLDYVAAKF HEEAGIFKLL IIDSIMALFR VDFSGRGELA ERQQKLAQML SRLQKISEEY NVAVFVTNQM TADPGATMTF QADPKKPIGG HILAHASTTR ISLRKGRGEL RIAKIYDSPE MPENEATFAI TAGGIGDAKE
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