About DNA replication licensing factor MCM6
DNA replication licensing factor MCM6 (MCM6) is a protein
from Homo sapiens identified by UniProt accession
Q14566, 821 residues long.
MolForge cross-references it against 0 known binders and
213 disease associations.
Target properties
| Protein name | DNA replication licensing factor MCM6 |
|---|
| UniProt accession | Q14566 |
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| Gene | MCM6 |
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| Organism | Homo sapiens |
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| Length | 821 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (213)
Diseases linked to this target (Open Targets).
- gut microbiome measurement · score 0.37
- lactose intolerance · score 0.32
- serum metabolite measurement · score 0.32
- endometrial cancer · score 0.26
- aspartate aminotransferase measurement · score 0.25
- lung adenocarcinoma · score 0.25
- systemic lupus erythematosus · score 0.24
- serum urea measurement · score 0.24
- total cholesterol measurement · score 0.24
- monocyte percentage of leukocytes · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14566-F1 | alphafold | PREDICTED | 76.43 | — |
Amino-acid sequence (821 residues)
MDLAAAAEPG AGSQHLEVRD EVAEKCQKLF LDFLEEFQSS DGEIKYLQLA EELIRPERNT LVVSFVDLEQ FNQQLSTTIQ EEFYRVYPYL CRALKTFVKD RKEIPLAKDF YVAFQDLPTR HKIRELTSSR IGLLTRISGQ VVRTHPVHPE LVSGTFLCLD CQTVIRDVEQ QFKYTQPNIC RNPVCANRRR FLLDTNKSRF VDFQKVRIQE TQAELPRGSI PRSLEVILRA EAVESAQAGD KCDFTGTLIV VPDVSKLSTP GARAETNSRV SGVDGYETEG IRGLRALGVR DLSYRLVFLA CCVAPTNPRF GGKELRDEEQ TAESIKNQMT VKEWEKVFEM SQDKNLYHNL CTSLFPTIHG NDEVKRGVLL MLFGGVPKTT GEGTSLRGDI NVCIVGDPST AKSQFLKHVE EFSPRAVYTS GKASSAAGLT AAVVRDEESH EFVIEAGALM LADNGVCCID EFDKMDVRDQ VAIHEAMEQQ TISITKAGVK ATLNARTSIL AAANPISGHY DRSKSLKQNI NLSAPIMSRF DLFFILVDEC NEVTDYAIAR RIVDLHSRIE ESIDRVYSLD DIRRYLLFAR QFKPKISKES EDFIVEQYKH LRQRDGSGVT KSSWRITVRQ LESMIRLSEA MARMHCCDEV QPKHVKEAFR LLNKSIIRVE TPDVNLDQEE EIQMEVDEGA GGINGHADSP APVNGINGYN EDINQESAPK ASLRLGFSEY CRISNLIVLH LRKVEEEEDE SALKRSELVN WYLKEIESEI DSEEELINKK RIIEKVIHRL THYDHVLIEL TQAGLKGSTE GSESYEEDPY LVVNPNYLLE D
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