Zinc finger protein 345 (ZNF345)

About Zinc finger protein 345

Zinc finger protein 345 (ZNF345) is a protein from Homo sapiens identified by UniProt accession Q14585, 488 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.

Target properties

Protein name	Zinc finger protein 345
UniProt accession	Q14585
Gene	ZNF345
Organism	Homo sapiens
Length	488 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (16)

Diseases linked to this target (Open Targets).

protein measurement · score 0.34
BMI-adjusted waist circumference · score 0.08
BMI-adjusted waist-hip ratio · score 0.08
grip strength measurement · score 0.06
platelet count · score 0.04
gait measurement · score 0.03
platelet crit · score 0.03
sex hormone-binding globulin measurement · score 0.03
insomnia measurement · score 0.02
appendicular lean mass · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14585-F1	alphafold	PREDICTED	82.04	—

Amino-acid sequence (488 residues)

MENLTKHSIE CSSFRGDWEC KNQFERKQGS QEGHFSEMIF TPEDMPTFSI QHQRIHTDEK LLECKECGKD FSFVSVLVRH QRIHTGEKPY ECKECGKAFG SGANLAYHQR IHTGEKPFEC KECGKAFGSG SNLTHHQRIH TGEKPYECKE CGKAFSFGSG LIRHQIIHSG EKPYECKECG KSFSFESALI RHHRIHTGEK PYECIDCGKA FGSGSNLTQH RRIHTGEKPY ECKACGMAFS SGSALTRHQR IHTGEKPYIC NECGKAFSFG SALTRHQRIH TGEKPYVCKE CGKAFNSGSD LTQHQRIHTG EKPYECKECE KAFRSGSKLI QHQRMHTGEK PYECKECGKT FSSGSDLTQH HRIHTGEKPY ECKECGKAFG SGSKLIQHQL IHTGERPYEC KECGKSFSSG SALNRHQRIH TGEKPYECKE CGKAFYSGSS LTQHQRIHTG EKLYECKNCG KAYGRDSEFQ QHKKSHNGKK LCELETIN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards