Zinc finger protein 460 (ZNF460)

About Zinc finger protein 460

Zinc finger protein 460 (ZNF460) is a protein from Homo sapiens identified by UniProt accession Q14592, 562 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.

Target properties

Protein name	Zinc finger protein 460
UniProt accession	Q14592
Gene	ZNF460
Organism	Homo sapiens
Length	562 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (20)

Diseases linked to this target (Open Targets).

heel bone mineral density · score 0.26
acute myeloid leukemia · score 0.20
body height · score 0.16
pancreatic adenocarcinoma · score 0.05
actinic keratosis · score 0.05
sebaceous of Jadassohn nevus · score 0.04
squamous cell carcinoma · score 0.04
breast cancer · score 0.03
oral squamous cell carcinoma · score 0.03
Intellectual disability · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14592-F1	alphafold	PREDICTED	66.10	—

Amino-acid sequence (562 residues)

MAAAWMAPAQ ESVTFEDVAV TFTQEEWGQL DVTQRALYVE VMLETCGLLV ALGDSTKPET VEPIPSHLAL PEEVSLQEQL AQGVPRYSYL GQAMDQDGPS EMQEYFLRPG TDPQSEKLHG KMSLEHEGLA TADGICSMMI QNQVSPEDAL YGFDSYGPVT DSLIHEGENS YKFEEMFNEN CFLVQHEQIL PRVKPYDCPE CGKAFGKSKH LLQHHIIHTG EKPYKCLECG KDFNRRSHLT RHQRTHNGDK PFVCSECGRT FNRGSHLTRH QRVHSGEKPF VCNECGKAFT YRSNFVLHNK SHNEKKPFAC SECGKGFYES TALIQHFIIH TGERPFKCLE CGKAFNCRSH LKQHERIHTG EKPFVCSQCG KAFTHYSTYV LHERAHTGEK PFECKECGKA FSIRKDLIRH FNIHTGEKPY ECLQCGKAFT RMSGLTRHQW IHTGEKPYVC IQCGKAFCRT TNLIRHFSIH TGEKPYECVE CGKAFNRRSP LTRHQRIHTA EKSHEPIQSG NVSCESTDLI QHSIIHTESS PVSAVNMETP SIAAHSSSLD INGFIVEETL PL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards