About Indian hedgehog protein
Indian hedgehog protein (IHH) is a protein
from Homo sapiens identified by UniProt accession
Q14623, 411 residues long.
MolForge cross-references it against 0 known binders and
535 disease associations.
Target properties
| Protein name | Indian hedgehog protein |
|---|
| UniProt accession | Q14623 |
|---|
| Gene | IHH |
|---|
| Organism | Homo sapiens |
|---|
| Length | 411 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (535)
Diseases linked to this target (Open Targets).
- brachydactyly type A1 · score 0.79
- acrocapitofemoral dysplasia · score 0.76
- body height · score 0.66
- forced expiratory volume · score 0.48
- brachydactyly type A1A · score 0.47
- syndactyly type 1 · score 0.38
- Hirschsprung disease · score 0.27
- lean body mass · score 0.25
- sitting height measurement · score 0.23
- genetic disorder · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14623-F1 | alphafold | PREDICTED | 84.34 | — |
Amino-acid sequence (411 residues)
MSPARLRPRL HFCLVLLLLL VVPAAWGCGP GRVVGSRRRP PRKLVPLAYK QFSPNVPEKT LGASGRYEGK IARSSERFKE LTPNYNPDII FKDEENTGAD RLMTQRCKDR LNSLAISVMN QWPGVKLRVT EGWDEDGHHS EESLHYEGRA VDITTSDRDR NKYGLLARLA VEAGFDWVYY ESKAHVHCSV KSEHSAAAKT GGCFPAGAQV RLESGARVAL SAVRPGDRVL AMGEDGSPTF SDVLIFLDRE PHRLRAFQVI ETQDPPRRLA LTPAHLLFTA DNHTEPAARF RATFASHVQP GQYVLVAGVP GLQPARVAAV STHVALGAYA PLTKHGTLVV EDVVASCFAA VADHHLAQLA FWPLRLFHSL AWGSWTPGEG VHWYPQLLYR LGRLLLEEGS FHPLGMSGAG S
Explore Indian hedgehog protein with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets