Interleukin-11 receptor subunit alpha (IL11RA)

About Interleukin-11 receptor subunit alpha

Interleukin-11 receptor subunit alpha (IL11RA) is a protein from Homo sapiens identified by UniProt accession Q14626, 422 residues long. MolForge cross-references it against 0 known binders and 146 disease associations.

Target properties

Protein name	Interleukin-11 receptor subunit alpha
UniProt accession	Q14626
Gene	IL11RA
Organism	Homo sapiens
Length	422 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (146)

Diseases linked to this target (Open Targets).

craniosynostosis and dental anomalies · score 0.77
craniosynostosis syndrome, autosomal recessive · score 0.55
Thrombocytopenia · score 0.40
neoplasm · score 0.39
craniosynostosis · score 0.37
body height · score 0.29
thyroid gland adenocarcinoma · score 0.23
neuroinflammatory disorder · score 0.23
appendicular lean mass · score 0.19
blood protein measurement · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14626-F1	alphafold	PREDICTED	81.54	—

Amino-acid sequence (422 residues)

MSSSCSGLSR VLVAVATALV SASSPCPQAW GPPGVQYGQP GRSVKLCCPG VTAGDPVSWF RDGEPKLLQG PDSGLGHELV LAQADSTDEG TYICQTLDGA LGGTVTLQLG YPPARPVVSC QAADYENFSC TWSPSQISGL PTRYLTSYRK KTVLGADSQR RSPSTGPWPC PQDPLGAARC VVHGAEFWSQ YRINVTEVNP LGASTRLLDV SLQSILRPDP PQGLRVESVP GYPRRLRASW TYPASWPCQP HFLLKFRLQY RPAQHPAWST VEPAGLEEVI TDAVAGLPHA VRVSARDFLD AGTWSTWSPE AWGTPSTGTI PKEIPAWGQL HTQPEVEPQV DSPAPPRPSL QPHPRLLDHR DSVEQVAVLA SLGILSFLGL VAGALALGLW LRLRRGGKDG SPKPGFLASV IPVDRRPGAP NL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards