Interleukin-13 receptor subunit alpha-2 (IL13RA2)

About Interleukin-13 receptor subunit alpha-2

Interleukin-13 receptor subunit alpha-2 (IL13RA2) is a protein from Homo sapiens identified by UniProt accession Q14627, 380 residues long. MolForge cross-references it against 0 known binders and 285 disease associations.

Target properties

Protein name	Interleukin-13 receptor subunit alpha-2
UniProt accession	Q14627
Gene	IL13RA2
Organism	Homo sapiens
Length	380 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (285)

Diseases linked to this target (Open Targets).

glioblastoma multiforme · score 0.34
head and neck squamous cell carcinoma · score 0.19
endometrial cancer · score 0.18
breast adenocarcinoma · score 0.18
gastric adenocarcinoma · score 0.15
esophageal cancer · score 0.15
neoplasm · score 0.12
hepatocellular carcinoma · score 0.09
papillary thyroid carcinoma · score 0.08
melanoma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14627-F1	alphafold	PREDICTED	86.16	—

Amino-acid sequence (380 residues)

MAFVCLAIGC LYTFLISTTF GCTSSSDTEI KVNPPQDFEI VDPGYLGYLY LQWQPPLSLD HFKECTVEYE LKYRNIGSET WKTIITKNLH YKDGFDLNKG IEAKIHTLLP WQCTNGSEVQ SSWAETTYWI SPQGIPETKV QDMDCVYYNW QYLLCSWKPG IGVLLDTNYN LFYWYEGLDH ALQCVDYIKA DGQNIGCRFP YLEASDYKDF YICVNGSSEN KPIRSSYFTF QLQNIVKPLP PVYLTFTRES SCEIKLKWSI PLGPIPARCF DYEIEIREDD TTLVTATVEN ETYTLKTTNE TRQLCFVVRS KVNIYCSDDG IWSEWSDKQC WEGEDLSKKT LLRFWLPFGF ILILVIFVTG LLLRKPNTYP KMIPEFFCDT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards