Early placenta insulin-like peptide (INSL4)

About Early placenta insulin-like peptide

Early placenta insulin-like peptide (INSL4) is a protein from Homo sapiens identified by UniProt accession Q14641, 139 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.

Target properties

Protein name	Early placenta insulin-like peptide
UniProt accession	Q14641
Gene	INSL4
Organism	Homo sapiens
Length	139 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (39)

Diseases linked to this target (Open Targets).

platelet count · score 0.31
neurodegenerative disease · score 0.22
IGF-1 measurement · score 0.21
ulcerative colitis · score 0.15
eosinophil percentage of leukocytes · score 0.15
platelet crit · score 0.14
mean platelet volume · score 0.09
non-small cell lung carcinoma · score 0.08
neoplasm · score 0.06
inflammatory bowel disease · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14641-F1	alphafold	PREDICTED	51.42	—

Amino-acid sequence (139 residues)

MASLFRSYLP AIWLLLSQLL RESLAAELRG CGPRFGKHLL SYCPMPEKTF TTTPGGWLLE SGRPKEMVST SNNKDGQALG TTSEFIPNLS PELKKPLSEG QPSLKKIILS RKKRSGRHRF DPFCCEVICD DGTSVKLCT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards