Inositol polyphosphate-5-phosphatase A (INPP5A)

About Inositol polyphosphate-5-phosphatase A

Inositol polyphosphate-5-phosphatase A (INPP5A) is a protein from Homo sapiens identified by UniProt accession Q14642, 412 residues long. MolForge cross-references it against 0 known binders and 102 disease associations.

Target properties

Protein name	Inositol polyphosphate-5-phosphatase A
UniProt accession	Q14642
Gene	INPP5A
Organism	Homo sapiens
Length	412 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (102)

Diseases linked to this target (Open Targets).

systolic blood pressure · score 0.50
heel bone mineral density · score 0.50
urate measurement · score 0.47
neurodegenerative disease · score 0.46
triglyceride measurement · score 0.46
pulse pressure measurement · score 0.41
bone quantitative ultrasound measurement · score 0.41
hypertension · score 0.40
cardiovascular disease · score 0.39
hematocrit · score 0.33

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14642-F1	alphafold	PREDICTED	91.38	—

Amino-acid sequence (412 residues)

MAGKAAAPGT AVLLVTANVG SLFDDPENLQ KNWLREFYQV VHTHKPHFMA LHCQEFGGKN YEASMSHVDK FVKELLSSDA MKEYNRARVY LDENYKSQEH FTALGSFYFL HESLKNIYQF DFKAKKYRKV AGKEIYSDTL ESTPMLEKEK FPQDYFPECK WSRKGFIRTR WCIADCAFDL VNIHLFHDAS NLVAWETSPS VYSGIRHKAL GYVLDRIIDQ RFEKVSYFVF GDFNFRLDSK SVVETLCTKA TMQTVRAADT NEVVKLIFRE SDNDRKVMLQ LEKKLFDYFN QEVFRDNNGT ALLEFDKELS VFKDRLYELD ISFPPSYPYS EDARQGEQYM NTRCPAWCDR ILMSPSAKEL VLRSESEEKV VTYDHIGPNV CMGDHKPVFL AFRIMPGAGK PHAHVHKCCV VQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards