About Plastin-1
Plastin-1 (PLS1) is a protein
from Homo sapiens identified by UniProt accession
Q14651, 629 residues long.
MolForge cross-references it against 0 known binders and
79 disease associations.
Target properties
| Protein name | Plastin-1 |
|---|
| UniProt accession | Q14651 |
|---|
| Gene | PLS1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 629 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (79)
Diseases linked to this target (Open Targets).
- hearing loss, autosomal dominant 76 · score 0.64
- autosomal dominant nonsyndromic hearing loss · score 0.44
- mean corpuscular volume · score 0.41
- mean corpuscular hemoglobin · score 0.41
- neurodegenerative disease · score 0.37
- red blood cell density measurement · score 0.32
- reticulocyte count · score 0.32
- Red cell distribution width · score 0.29
- reticulocyte measurement · score 0.28
- Sensorineural hearing impairment · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14651-F1 | alphafold | PREDICTED | 87.32 | — |
Amino-acid sequence (629 residues)
MENSTTTISR EELEELQEAF NKIDIDNSGY VSDYELQDLF KEASLPLPGY KVREIVEKIL SVADSNKDGK ISFEEFVSLM QELKSKDISK TFRKIINKRE GITAIGGTST ISSEGTQHSY SEEEKVAFVN WINKALENDP DCKHLIPMNP NDDSLFKSLA DGILLCKMIN LSEPDTIDER AINKKKLTPF TISENLNLAL NSASAIGCTV VNIGASDLKE GKPHLVLGLL WQIIKVGLFA DIEISRNEAL IALLNEGEEL EELMKLSPEE LLLRWVNYHL TNAGWHTISN FSQDIKDSRA YFHLLNQIAP KGGEDGPAIA IDLSGINETN DLKRAGLMLQ EADKLGCKQF VTPADVVSGN PKLNLAFVAN LFNTYPCLHK PNNNDIDMNL LEGESKEERT FRNWMNSLGV NPYINHLYSD LADALVIFQL YEMIRVPVNW SHVNKPPYPA LGGNMKKIEN CNYAVELGKN KAKFSLVGIA GQDLNEGNST LTLALVWQLM RRYTLNVLSD LGEGEKVNDE IIIKWVNQTL KSANKKTSIS SFKDKSISTS LPVLDLIDAI APNAVRQEMI RRENLSDEDK LNNAKYAISV ARKIGARIYA LPDDLVEVKP KMVMTVFACL MGKGLNRIK
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