Interferon regulatory factor 3 (IRF3)

About Interferon regulatory factor 3

Interferon regulatory factor 3 (IRF3) is a protein from Homo sapiens identified by UniProt accession Q14653, 427 residues long. MolForge cross-references it against 0 known binders and 491 disease associations.

Target properties

Protein name	Interferon regulatory factor 3
UniProt accession	Q14653
Gene	IRF3
Organism	Homo sapiens
Length	427 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (491)

Diseases linked to this target (Open Targets).

Herpetic encephalitis · score 0.56
severe acute respiratory syndrome · score 0.47
COVID-19 · score 0.47
neurodegenerative disease · score 0.36
cutaneous melanoma · score 0.30
schizophrenia · score 0.30
skin squamous cell carcinoma · score 0.26
serum albumin measurement · score 0.25
endometrial cancer · score 0.23
ovarian cancer · score 0.21

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14653-F1	alphafold	PREDICTED	80.26	—

Amino-acid sequence (427 residues)

MGTPKPRILP WLVSQLDLGQ LEGVAWVNKS RTRFRIPWKH GLRQDAQQED FGIFQAWAEA TGAYVPGRDK PDLPTWKRNF RSALNRKEGL RLAEDRSKDP HDPHKIYEFV NSGVGDFSQP DTSPDTNGGG STSDTQEDIL DELLGNMVLA PLPDPGPPSL AVAPEPCPQP LRSPSLDNPT PFPNLGPSEN PLKRLLVPGE EWEFEVTAFY RGRQVFQQTI SCPEGLRLVG SEVGDRTLPG WPVTLPDPGM SLTDRGVMSY VRHVLSCLGG GLALWRAGQW LWAQRLGHCH TYWAVSEELL PNSGHGPDGE VPKDKEGGVF DLGPFIVDLI TFTEGSGRSP RYALWFCVGE SWPQDQPWTK RLVMVKVVPT CLRALVEMAR VGGASSLENT VDLHISNSHP LSLTSDQYKA YLQDLVEGMD FQGPGES

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards