EKC/KEOPS complex subunit LAGE3 (LAGE3)

About EKC/KEOPS complex subunit LAGE3

EKC/KEOPS complex subunit LAGE3 (LAGE3) is a protein from Homo sapiens identified by UniProt accession Q14657, 143 residues long. MolForge cross-references it against 0 known binders and 69 disease associations.

Target properties

Protein name	EKC/KEOPS complex subunit LAGE3
UniProt accession	Q14657
Gene	LAGE3
Organism	Homo sapiens
Length	143 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (69)

Diseases linked to this target (Open Targets).

Galloway-Mowat syndrome 2, X-linked · score 0.70
neurodegenerative disease · score 0.48
Galloway-Mowat syndrome · score 0.37
lysosomal storage disease · score 0.31
hepatocellular carcinoma · score 0.10
breast cancer · score 0.08
triple-negative breast cancer · score 0.07
neoplasm · score 0.07
cancer · score 0.06
cervical rib syndrome · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14657-F1	alphafold	PREDICTED	74.14	—

Amino-acid sequence (143 residues)

MRDADADAGG GADGGDGRGG HSCRGGVDTA AAPAGGAPPA HAPGPGRDAA SAARGSRMRP HIFTLSVPFP TPLEAEIAHG SLAPDAEPHQ RVVGKDLTVS GRILVVRWKA EDCRLLRISV INFLDQLSLV VRTMQRFGPP VSR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards