E3 ubiquitin-protein ligase TRIP12 (TRIP12)

About E3 ubiquitin-protein ligase TRIP12

E3 ubiquitin-protein ligase TRIP12 (TRIP12) is a protein from Homo sapiens identified by UniProt accession Q14669, 2067 residues long. MolForge cross-references it against 0 known binders and 80 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase TRIP12
UniProt accession	Q14669
Gene	TRIP12
Organism	Homo sapiens
Length	2067 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (80)

Diseases linked to this target (Open Targets).

Clark-Baraitser syndrome · score 0.74
neurodegenerative disease · score 0.58
genetic disorder · score 0.52
Intellectual disability · score 0.47
complex neurodevelopmental disorder · score 0.46
Neurodevelopmental disorder · score 0.45
body mass index · score 0.41
lysosomal storage disease · score 0.37
vital capacity · score 0.36
Neurodevelopmental delay · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14669-F1	alphafold	PREDICTED	66.77	—

Amino-acid sequence (2067 residues)

MSNRPNNNPG GSLRRSQRNT AGAQPQDDSI GGRSHLGQAK HKGYSPPESR KSNSKAPKVQ SNTTSELSRG HLSKRSCSSS SAVIVPQPED PDRANTSERQ KTGQVPKKDN SRGVKRSASP DYNRTNSPSS AKKPKALQHT ESPSETNKPH SKSKKRHLDQ EQQLKSAQSP STSKAHTRKS GATGGSRSQK RKRTESSCVK SGSGSESTGA EERSAKPTKL ASKSATSAKA GCSTITDSSS AASTSSSSSA VASASSTVPP GARVKQGKDQ NKARRSRSAS SPSPRRSSRE KEQSKTGGSS KFDWAARFSP KVSLPKTKLS LPGSSKSETS KPGPSGLQAK LASLRKSTKK RSESPPAELP SLRRSTRQKT TGSCASTSRR GSGLGKRGAA EARRQEKMAD PESNQEAVNS SAARTDEAPQ GAAASSSVAG AVGMTTSGES ESDDSEMGRL QALLEARGLP PHLFGPLGPR MSQLFHRTIG SGASSKAQQL LQGLQASDES QQLQAVIEMC QLLVMGNEET LGGFPVKSVV PALITLLQME HNFDIMNHAC RALTYMMEAL PRSSAVVVDA IPVFLEKLQV IQCIDVAEQA LTALEMLSRR HSKAILQAGG LADCLLYLEF FSINAQRNAL AIAANCCQSI TPDEFHFVAD SLPLLTQRLT HQDKKSVEST CLCFARLVDN FQHEENLLQQ VASKDLLTNV QQLLVVTPPI LSSGMFIMVV RMFSLMCSNC PTLAVQLMKQ NIAETLHFLL CGASNGSCQE QIDLVPRSPQ ELYELTSLIC ELMPCLPKEG IFAVDTMLKK GNAQNTDGAI WQWRDDRGLW HPYNRIDSRI IEAAHQVGED EISLSTLGRV YTIDFNSMQQ INEDTGTARA IQRKPNPLAN SNTSGYSESK KDDARAQLMK EDPELAKSFI KTLFGVLYEV YSSSAGPAVR HKCLRAILRI IYFADAELLK DVLKNHAVSS HIASMLSSQD LKIVVGALQM AEILMQKLPD IFSVYFRREG VMHQVKHLAE SESLLTSPPK ACTNGSGSMG STTSVSSGTA TAATHAAADL GSPSLQHSRD DSLDLSPQGR LSDVLKRKRL PKRGPRRPKY SPPRDDDKVD NQAKSPTTTQ SPKSSFLASL NPKTWGRLST QSNSNNIEPA RTAGGSGLAR AASKDTISNN REKIKGWIKE QAHKFVERYF SSENMDGSNP ALNVLQRLCA ATEQLNLQVD GGAECLVEIR SIVSESDVSS FEIQHSGFVK QLLLYLTSKS EKDAVSREIR LKRFLHVFFS SPLPGEEPIG RVEPVGNAPL LALVHKMNNC LSQMEQFPVK VHDFPSGNGT GGSFSLNRGS QALKFFNTHQ LKCQLQRHPD CANVKQWKGG PVKIDPLALV QAIERYLVVR GYGRVREDDE DSDDDGSDEE IDESLAAQFL NSGNVRHRLQ FYIGEHLLPY NMTVYQAVRQ FSIQAEDERE STDDESNPLG RAGIWTKTHT IWYKPVREDE ESNKDCVGGK RGRAQTAPTK TSPRNAKKHD ELWHDGVCPS VSNPLEVYLI PTPPENITFE DPSLDVILLL RVLHAISRYW YYLYDNAMCK EIIPTSEFIN SKLTAKANRQ LQDPLVIMTG NIPTWLTELG KTCPFFFPFD TRQMLFYVTA FDRDRAMQRL LDTNPEINQS DSQDSRVAPR LDRKKRTVNR EELLKQAESV MQDLGSSRAM LEIQYENEVG TGLGPTLEFY ALVSQELQRA DLGLWRGEEV TLSNPKGSQE GTKYIQNLQG LFALPFGRTA KPAHIAKVKM KFRFLGKLMA KAIMDFRLVD LPLGLPFYKW MLRQETSLTS HDLFDIDPVV ARSVYHLEDI VRQKKRLEQD KSQTKESLQY ALETLTMNGC SVEDLGLDFT LPGFPNIELK KGGKDIPVTI HNLEEYLRLV IFWALNEGVS RQFDSFRDGF ESVFPLSHLQ YFYPEELDQL LCGSKADTWD AKTLMECCRP DHGYTHDSRA VKFLFEILSS FDNEQQRLFL QFVTGSPRLP VGGFRSLNPP LTIVRKTFES TENPDDFLPS VMTCVNYLKL PDYSSIEIMR EKLLIAAREG QQSFHLS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards