About Clathrin interactor 1
Clathrin interactor 1 (CLINT1) is a protein
from Homo sapiens identified by UniProt accession
Q14677, 625 residues long.
MolForge cross-references it against 0 known binders and
56 disease associations.
Target properties
| Protein name | Clathrin interactor 1 |
|---|
| UniProt accession | Q14677 |
|---|
| Gene | CLINT1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 625 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (56)
Diseases linked to this target (Open Targets).
- platelet component distribution width · score 0.33
- neurodegenerative disease · score 0.31
- mean platelet volume · score 0.30
- Parkinson disease · score 0.18
- Alzheimer disease · score 0.18
- multiple sclerosis · score 0.18
- lysosomal storage disease · score 0.18
- self reported educational attainment · score 0.17
- mathematical ability · score 0.17
- hypertension · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14677-F1 | alphafold | PREDICTED | 56.79 | — |
Amino-acid sequence (625 residues)
MLNMWKVREL VDKATNVVMN YSEIESKVRE ATNDDPWGPS GQLMGEIAKA TFMYEQFPEL MNMLWSRMLK DNKKNWRRVY KSLLLLAYLI RNGSERVVTS AREHIYDLRS LENYHFVDEH GKDQGINIRQ KVKELVEFAQ DDDRLREERK KAKKNKDKYV GVSSDSVGGF RYSERYDPEP KSKWDEEWDK NKSAFPFSDK LGELSDKIGS TIDDTISKFR RKDREDSPER CSDSDEEKKA RRGRSPKGEF KDEEETVTTK HIHITQATET TTTRHKRTAN PSKTIDLGAA AHYTGDKASP DQNASTHTPQ SSVKTSVPSS KSSGDLVDLF DGTSQSTGGS ADLFGGFADF GSAAASGSFP SQVTATSGNG DFGDWSAFNQ APSGPVASSG EFFGSASQPA VELVSGSQSA LGPPPAASNS SDLFDLMGSS QATMTSSQSM NFSMMSTNTV GLGLPMSRSQ NTDMVQKSVS KTLPSTWSDP SVNISLDNLL PGMQPSKPQQ PSLNTMIQQQ NMQQPMNVMT QSFGAVNLSS PSNMLPVRPQ TNALIGGPMP MSMPNVMTGT MGMAPLGNTP MMNQSMMGMN MNIGMSAAGM GLTGTMGMGM PNIAMTSGTV QPKQDAFANF ANFSK
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