About Maternal embryonic leucine zipper kinase
Maternal embryonic leucine zipper kinase (MELK) is a protein
from Homo sapiens identified by UniProt accession
Q14680, 651 residues long.
MolForge cross-references it against 0 known binders and
156 disease associations.
Target properties
| Protein name | Maternal embryonic leucine zipper kinase |
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| UniProt accession | Q14680 |
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| Gene | MELK |
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| Organism | Homo sapiens |
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| Length | 651 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (12)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (156)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- hepatocellular carcinoma · score 0.12
- Hereditary breast and ovarian cancer syndrome · score 0.12
- hereditary breast ovarian cancer syndrome · score 0.12
- neoplasm · score 0.12
- cancer · score 0.11
- lung adenocarcinoma · score 0.11
- glioblastoma multiforme · score 0.11
- breast cancer · score 0.10
- nonpapillary renal cell carcinoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14680-F1 | alphafold | PREDICTED | 69.68 | — |
Amino-acid sequence (651 residues)
MKDYDELLKY YELHETIGTG GFAKVKLACH ILTGEMVAIK IMDKNTLGSD LPRIKTEIEA LKNLRHQHIC QLYHVLETAN KIFMVLEYCP GGELFDYIIS QDRLSEEETR VVFRQIVSAV AYVHSQGYAH RDLKPENLLF DEYHKLKLID FGLCAKPKGN KDYHLQTCCG SLAYAAPELI QGKSYLGSEA DVWSMGILLY VLMCGFLPFD DDNVMALYKK IMRGKYDVPK WLSPSSILLL QQMLQVDPKK RISMKNLLNH PWIMQDYNYP VEWQSKNPFI HLDDDCVTEL SVHHRNNRQT MEDLISLWQY DHLTATYLLL LAKKARGKPV RLRLSSFSCG QASATPFTDI KSNNWSLEDV TASDKNYVAG LIDYDWCEDD LSTGAATPRT SQFTKYWTES NGVESKSLTP ALCRTPANKL KNKENVYTPK SAVKNEEYFM FPEPKTPVNK NQHKREILTT PNRYTTPSKA RNQCLKETPI KIPVNSTGTD KLMTGVISPE RRCRSVELDL NQAHMEETPK RKGAKVFGSL ERGLDKVITV LTRSKRKGSA RDGPRRLKLH YNVTTTRLVN PDQLLNEIMS ILPKKHVDFV QKGYTLKCQT QSDFGKVTMQ FELEVCQLQK PDVVGIRRQR LKGDAWVYKR LVEDILSSCK V
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