BTB/POZ domain-containing protein KCTD2 (KCTD2)

About BTB/POZ domain-containing protein KCTD2

BTB/POZ domain-containing protein KCTD2 (KCTD2) is a protein from Homo sapiens identified by UniProt accession Q14681, 263 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.

Target properties

Protein name	BTB/POZ domain-containing protein KCTD2
UniProt accession	Q14681
Gene	KCTD2
Organism	Homo sapiens
Length	263 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (52)

Diseases linked to this target (Open Targets).

lymphocyte percentage of leukocytes · score 0.21
lymphocyte count · score 0.20
neutrophil percentage of leukocytes · score 0.17
small vessel stroke · score 0.09
Alzheimer disease · score 0.09
sex hormone-binding globulin measurement · score 0.07
macrothrombocytopenia, isolated, 2, autosomal dominant · score 0.07
thrombocytopenia 4 · score 0.06
autosomal dominant macrothrombocytopenia · score 0.05
beta-thalassemia-X-linked thrombocytopenia syndrome · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14681-F1	alphafold	PREDICTED	73.37	—

Amino-acid sequence (263 residues)

MAELQLDPAM AGLGGGGGSG VGDGGGPVRG PPSPRPAGPT PRGHGRPAAA VAQPLEPGPG PPERAGGGGA ARWVRLNVGG TYFVTTRQTL GREPKSFLCR LCCQEDPELD SDKDETGAYL IDRDPTYFGP ILNYLRHGKL IITKELAEEG VLEEAEFYNI ASLVRLVKER IRDNENRTSQ GPVKHVYRVL QCQEEELTQM VSTMSDGWKF EQLISIGSSY NYGNEDQAEF LCVVSRELNN STNGIVIEPS EKAKILQERG SRM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards