About Ribosomal RNA processing protein 1 homolog B
Ribosomal RNA processing protein 1 homolog B (RRP1B) is a protein
from Homo sapiens identified by UniProt accession
Q14684, 758 residues long.
MolForge cross-references it against 0 known binders and
36 disease associations.
Target properties
| Protein name | Ribosomal RNA processing protein 1 homolog B |
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| UniProt accession | Q14684 |
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| Gene | RRP1B |
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| Organism | Homo sapiens |
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| Length | 758 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (36)
Diseases linked to this target (Open Targets).
- systolic blood pressure · score 0.30
- diastolic blood pressure · score 0.28
- mean corpuscular hemoglobin · score 0.20
- hypertension · score 0.18
- mean corpuscular volume · score 0.16
- Abnormality of refraction · score 0.14
- erythrocyte count · score 0.13
- mean corpuscular hemoglobin concentration · score 0.13
- cardiovascular disease · score 0.12
- eosinophil count · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14684-F1 | alphafold | PREDICTED | 59.50 | — |
Amino-acid sequence (758 residues)
MAPAMQPAEI QFAQRLASSE KGIRDRAVKK LRQYISVKTQ RETGGFSQEE LLKIWKGLFY CMWVQDEPLL QEELANTIAQ LVHAVNNSAA QHLFIQTFWQ TMNREWKGID RLRLDKYYML IRLVLRQSFE VLKRNGWEES RIKVFLDVLM KEVLCPESQS PNGVRFHFID IYLDELSKVG GKELLADQNL KFIDPFCKIA AKTKDHTLVQ TIARGVFEAI VDQSPFVPEE TMEEQKTKVG DGDLSAEEIP ENEVSLRRAV SKKKTALGKN HSRKDGLSDE RGRDDCGTFE DTGPLLQFDY KAVADRLLEM TSRKNTPHFN RKRLSKLIKK FQDLSEGSSI SQLSFAEDIS ADEDDQILSQ GKHKKKGNKL LEKTNLEKEK GSRVFCVEEE DSESSLQKRR RKKKKKHHLQ PENPGPGGAA PSLEQNRGRE PEASGLKALK ARVAEPGAEA TSSTGEESGS EHPPAVPMHN KRKRPRKKSP RAHREMLESA VLPPEDMSQS GPSGSHPQGP RGSPTGGAQL LKRKRKLGVV PVNGSGLSTP AWPPLQQEGP PTGPAEGANS HTTLPQRRRL QKKKAGPGSL ELCGLPSQKT ASLKKRKKMR VMSNLVEHNG VLESEAGQPQ ALGSSGTCSS LKKQKLRAES DFVKFDTPFL PKPLFFRRAK SSTATHPPGP AVQLNKTPSS SKKVTFGLNR NMTAEFKKTD KSILVSPTGP SRVAFDPEQK PLHGVLKTPT SSPASSPLVA KKPLTTTPRR RPRAMDFF
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