About LRP chaperone MESD
LRP chaperone MESD (MESD) is a protein
from Homo sapiens identified by UniProt accession
Q14696, 234 residues long.
MolForge cross-references it against 0 known binders and
26 disease associations.
Target properties
| Protein name | LRP chaperone MESD |
|---|
| UniProt accession | Q14696 |
|---|
| Gene | MESD |
|---|
| Organism | Homo sapiens |
|---|
| Length | 234 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (26)
Diseases linked to this target (Open Targets).
- osteogenesis imperfecta · score 0.69
- osteogenesis imperfecta type 2 · score 0.37
- IGF-1 measurement · score 0.21
- neutrophil percentage of leukocytes · score 0.19
- gut microbiome measurement · score 0.18
- cancer · score 0.02
- breast cancer · score 0.01
- neoplasm · score 0.01
- triple-negative breast cancer · score 0.01
- adenoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14696-F1 | alphafold | PREDICTED | 67.13 | — |
Amino-acid sequence (234 residues)
MAASRWARKA VVLLCASDLL LLLLLLPPPG SCAAEGSPGT PDESTPPPRK KKKDIRDYND ADMARLLEQW EKDDDIEEGD LPEHKRPSAP VDFSKIDPSK PESILKMTKK GKTLMMFVTV SGSPTEKETE EITSLWQGSL FNANYDVQRF IVGSDRAIFM LRDGSYAWEI KDFLVGQDRC ADVTLEGQVY PGKGGGSKEK NKTKQDKGKK KKEGDLKSRS SKEENRAGNK REDL
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