About Raftlin
Raftlin (RFTN1) is a protein
from Homo sapiens identified by UniProt accession
Q14699, 578 residues long.
MolForge cross-references it against 0 known binders and
120 disease associations.
Target properties
| Protein name | Raftlin |
|---|
| UniProt accession | Q14699 |
|---|
| Gene | RFTN1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 578 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (120)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.49
- neurofibrillary tangles measurement · score 0.32
- lysosomal storage disease · score 0.29
- Testicular Germ Cell Tumor · score 0.18
- testicular carcinoma · score 0.13
- body height · score 0.07
- lung adenocarcinoma · score 0.06
- common variable immunodeficiency · score 0.05
- chronic rhinosinusitis with nasal polyps · score 0.05
- autoimmune lymphoproliferative syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14699-F1 | alphafold | PREDICTED | 64.17 | — |
Amino-acid sequence (578 residues)
MGCGLNKLEK RDEKRPGNIY STLKRPQVET KIDVSYEYRF LEFTTLSAAE LPGSSAVRLA SLRDLPAQLL ELYQQGFSLA ALHPFVQPTH EREKTPLEHI FRAILIKKTD RSQKTDLHNE GYILELDCCS SLDHPTDQKL IPEFIKKIQE AASQGLKFVG VIPQYHSSVN SAGSSAPVST ANSTEDARDA KNARGDHASL ENEKPGTGDV CSAPAGRNQS PEPSSGPRGE VPLAKQPSSP SGEGDGGELS PQGVSKTLDG PESNPLEVHE EPLSGKMEIF TLFNKPKSHQ KCRQYYPVTI PLHVSKNGQT VSGLDANWLE HMSDHFRKGG MLVNAVFYLG IVNDSLHGLT DGVFIFEAVS TEDSKTIQGY DAIVVEQWTV LEGVEVQTDY VPLLNSLAAY GWQLTCVLPT PVVKTTSEGS VSTKQIVFLQ RPCLPQKIKK KESKFQWRFS REEMHNRQMR KSKGKLSARD KQQAEENEKN LEDQSSKAGD MGNCVSGQQQ EGGVSEEMKG PVQEDKGEQL SPGGLLCGVG VEGEAVQNGP ASHSRALVGI CTGHSNPGED ARDGDAEEVR ELGTVEEN
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