About Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) is a protein
from Homo sapiens identified by UniProt accession
Q14738, 602 residues long.
MolForge cross-references it against 0 known binders and
94 disease associations.
Target properties
| Protein name | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform |
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| UniProt accession | Q14738 |
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| Gene | PPP2R5D |
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| Organism | Homo sapiens |
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| Length | 602 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (94)
Diseases linked to this target (Open Targets).
- Hogue-Janssens syndrome 1 · score 0.76
- Intellectual disability · score 0.69
- cancer · score 0.53
- neurodegenerative disease · score 0.53
- genetic disorder · score 0.51
- chronic myelogenous leukemia · score 0.37
- syndromic intellectual disability · score 0.37
- Neurodevelopmental disorder · score 0.35
- Neurodevelopmental delay · score 0.34
- Global developmental delay · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14738-F1 | alphafold | PREDICTED | 79.95 | — |
Amino-acid sequence (602 residues)
MPYKLKKEKE PPKVAKCTAK PSSSGKDGGG ENTEEAQPQP QPQPQPQAQS QPPSSNKRPS NSTPPPTQLS KIKYSGGPQI VKKERRQSSS RFNLSKNREL QKLPALKDSP TQEREELFIQ KLRQCCVLFD FVSDPLSDLK FKEVKRAGLN EMVEYITHSR DVVTEAIYPE AVTMFSVNLF RTLPPSSNPT GAEFDPEEDE PTLEAAWPHL QLVYEFFLRF LESPDFQPNI AKKYIDQKFV LALLDLFDSE DPRERDFLKT ILHRIYGKFL GLRAYIRRQI NHIFYRFIYE TEHHNGIAEL LEILGSIING FALPLKEEHK MFLIRVLLPL HKVKSLSVYH PQLAYCVVQF LEKESSLTEP VIVGLLKFWP KTHSPKEVMF LNELEEILDV IEPSEFSKVM EPLFRQLAKC VSSPHFQVAE RALYYWNNEY IMSLISDNAA RVLPIMFPAL YRNSKSHWNK TIHGLIYNAL KLFMEMNQKL FDDCTQQYKA EKQKGRFRMK EREEMWQKIE ELARLNPQYP MFRAPPPLPP VYSMETETPT AEDIQLLKRT VETEAVQMLK DIKKEKVLLR RKSELPQDVY TIKALEAHKR AEEFLTASQE AL
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