About Delta(14)-sterol reductase LBR
Delta(14)-sterol reductase LBR (LBR) is a protein
from Homo sapiens identified by UniProt accession
Q14739, 615 residues long.
MolForge cross-references it against 0 known binders and
408 disease associations.
Target properties
| Protein name | Delta(14)-sterol reductase LBR |
|---|
| UniProt accession | Q14739 |
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| Gene | LBR |
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| Organism | Homo sapiens |
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| Length | 615 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (408)
Diseases linked to this target (Open Targets).
- Greenberg dysplasia · score 0.82
- regressive spondylometaphyseal dysplasia · score 0.74
- Pelger-Huet anomaly · score 0.71
- Reynolds syndrome · score 0.45
- Jeune syndrome · score 0.42
- mean corpuscular volume · score 0.41
- mean corpuscular hemoglobin concentration · score 0.39
- Mesomelia · score 0.37
- Rhizomelia · score 0.37
- Polydactyly · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14739-F1 | alphafold | PREDICTED | 76.63 | — |
Amino-acid sequence (615 residues)
MPSRKFADGE VVRGRWPGSS LYYEVEILSH DSTSQLYTVK YKDGTELELK ENDIKPLTSF RQRKGGSTSS SPSRRRGSRS RSRSRSPGRP PKSARRSASA SHQADIKEAR REVEVKLTPL ILKPFGNSIS RYNGEPEHIE RNDAPHKNTQ EKFSLSQESS YIATQYSLRP RREEVKLKEI DSKEEKYVAK ELAVRTFEVT PIRAKDLEFG GVPGVFLIMF GLPVFLFLLL LMCKQKDPSL LNFPPPLPAL YELWETRVFG VYLLWFLIQV LFYLLPIGKV VEGTPLIDGR RLKYRLNGFY AFILTSAVIG TSLFQGVEFH YVYSHFLQFA LAATVFCVVL SVYLYMRSLK APRNDLSPAS SGNAVYDFFI GRELNPRIGT FDLKYFCELR PGLIGWVVIN LVMLLAEMKI QDRAVPSLAM ILVNSFQLLY VVDALWNEEA LLTTMDIIHD GFGFMLAFGD LVWVPFIYSF QAFYLVSHPN EVSWPMASLI IVLKLCGYVI FRGANSQKNA FRKNPSDPKL AHLKTIHTST GKNLLVSGWW GFVRHPNYLG DLIMALAWSL PCGFNHILPY FYIIYFTMLL VHREARDEYH CKKKYGVAWE KYCQRVPYRI FPYIY
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