About Conserved oligomeric Golgi complex subunit 2
Conserved oligomeric Golgi complex subunit 2 (COG2) is a protein
from Homo sapiens identified by UniProt accession
Q14746, 738 residues long.
MolForge cross-references it against 0 known binders and
104 disease associations.
Target properties
| Protein name | Conserved oligomeric Golgi complex subunit 2 |
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| UniProt accession | Q14746 |
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| Gene | COG2 |
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| Organism | Homo sapiens |
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| Length | 738 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (104)
Diseases linked to this target (Open Targets).
- congenital disorder of glycosylation, type IIq · score 0.65
- neurodegenerative disease · score 0.47
- congenital disorder of glycosylation type II · score 0.37
- mastiha supplement exposure measurement · score 0.16
- interleukin-6 gene expression measurement · score 0.16
- breast adenocarcinoma · score 0.10
- cerebrospinal fluid biomarker measurement · score 0.07
- systolic blood pressure · score 0.07
- diastolic blood pressure · score 0.07
- metabolite measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14746-F1 | alphafold | PREDICTED | 80.75 | — |
Amino-acid sequence (738 residues)
MEKSRMNLPK GPDTLCFDKD EFMKEDFDVD HFVSDCRKRV QLEELRDDLE LYYKLLKTAM VELINKDYAD FVNLSTNLVG MDKALNQLSV PLGQLREEVL SLRSSVSEGI RAVDERMSKQ EDIRKKKMCV LRLIQVIRSV EKIEKILNSQ SSKETSALEA SSPLLTGQIL ERIATEFNQL QFHAVQSKGM PLLDKVRPRI AGITAMLQQS LEGLLLEGLQ TSDVDIIRHC LRTYATIDKT RDAEALVGQV LVKPYIDEVI IEQFVESHPN GLQVMYNKLL EFVPHHCRLL REVTGGAISS EKGNTVPGYD FLVNSVWPQI VQGLEEKLPS LFNPGNPDAF HEKYTISMDF VRRLERQCGS QASVKRLRAH PAYHSFNKKW NLPVYFQIRF REIAGSLEAA LTDVLEDAPA ESPYCLLASH RTWSSLRRCW SDEMFLPLLV HRLWRLTLQI LARYSVFVNE LSLRPISNES PKEIKKPLVT GSKEPSITQG NTEDQGSGPS ETKPVVSISR TQLVYVVADL DKLQEQLPEL LEIIKPKLEM IGFKNFSSIS AALEDSQSSF SACVPSLSSK IIQDLSDSCF GFLKSALEVP RLYRRTNKEV PTTASSYVDS ALKPLFQLQS GHKDKLKQAI IQQWLEGTLS ESTHKYYETV SDVLNSVKKM EESLKRLKQA RKTTPANPVG PSGGMSDDDK IRLQLALDVE YLGEQIQKLG LQASDIKSFS ALAELVAAAK DQATAEQP
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