Glycine N-methyltransferase (GNMT)

About Glycine N-methyltransferase

Glycine N-methyltransferase (GNMT) is a protein from Homo sapiens identified by UniProt accession Q14749, 295 residues long. MolForge cross-references it against 0 known binders and 226 disease associations.

Target properties

Protein name	Glycine N-methyltransferase
UniProt accession	Q14749
Gene	GNMT
Organism	Homo sapiens
Length	295 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (226)

Diseases linked to this target (Open Targets).

glycine N-methyltransferase deficiency · score 0.72
apolipoprotein A 1 measurement · score 0.26
neurodegenerative disease · score 0.24
protein measurement · score 0.23
blood protein measurement · score 0.23
bilirubin measurement · score 0.21
hematocrit · score 0.20
high density lipoprotein cholesterol measurement · score 0.17
apolipoprotein B measurement · score 0.17
low density lipoprotein cholesterol measurement · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14749-F1	alphafold	PREDICTED	88.39	—

Amino-acid sequence (295 residues)

MVDSVYRTRS LGVAAEGLPD QYADGEAARV WQLYIGDTRS RTAEYKAWLL GLLRQHGCQR VLDVACGTGV DSIMLVEEGF SVTSVDASDK MLKYALKERW NRRHEPAFDK WVIEEANWMT LDKDVPQSAE GGFDAVICLG NSFAHLPDCK GDQSEHRLAL KNIASMVRAG GLLVIDHRNY DHILSTGCAP PGKNIYYKSD LTKDVTTSVL IVNNKAHMVT LDYTVQVPGA GQDGSPGLSK FRLSYYPHCL ASFTELLQAA FGGKCQHSVL GDFKPYKPGQ TYIPCYFIHV LKRTD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards