Intercellular adhesion molecule 4 (ICAM4)

About Intercellular adhesion molecule 4

Intercellular adhesion molecule 4 (ICAM4) is a protein from Homo sapiens identified by UniProt accession Q14773, 271 residues long. MolForge cross-references it against 0 known binders and 98 disease associations.

Target properties

Protein name	Intercellular adhesion molecule 4
UniProt accession	Q14773
Gene	ICAM4
Organism	Homo sapiens
Length	271 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (98)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.33
breast adenocarcinoma · score 0.22
ICAM-1 measurement · score 0.20
leukocyte count · score 0.14
lymphocyte count · score 0.14
neutrophil-to-lymphocyte ratio · score 0.10
platelet crit · score 0.09
Blackfan-Diamond anemia · score 0.08
serum gamma-glutamyl transferase measurement · score 0.08
intercellular adhesion molecule 5 measurement · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14773-F1	alphafold	PREDICTED	83.22	—

Amino-acid sequence (271 residues)

MGSLFPLSLL FFLAAAYPGV GSALGRRTKR AQSPKGSPLA PSGTSVPFWV RMSPEFVAVQ PGKSVQLNCS NSCPQPQNSS LRTPLRQGKT LRGPGWVSYQ LLDVRAWSSL AHCLVTCAGK TRWATSRITA YKPPHSVILE PPVLKGRKYT LRCHVTQVFP VGYLVVTLRH GSRVIYSESL ERFTGLDLAN VTLTYEFAAG PRDFWQPVIC HARLNLDGLV VRNSSAPITL MLAWSPAPTA LASGSIAALV GILLTVGAAY LCKCLAMKSQ A

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards