H2.0-like homeobox protein (HLX)

About H2.0-like homeobox protein

H2.0-like homeobox protein (HLX) is a protein from Homo sapiens identified by UniProt accession Q14774, 488 residues long. MolForge cross-references it against 0 known binders and 148 disease associations.

Target properties

Protein name	H2.0-like homeobox protein
UniProt accession	Q14774
Gene	HLX
Organism	Homo sapiens
Length	488 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (148)

Diseases linked to this target (Open Targets).

eosinophil count · score 0.47
monocyte count · score 0.45
sex hormone-binding globulin measurement · score 0.45
neutrophil count · score 0.44
vital capacity · score 0.44
monocyte percentage of leukocytes · score 0.43
leukocyte count · score 0.43
C-reactive protein measurement · score 0.42
IGF-1 measurement · score 0.42
appendicitis · score 0.41

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14774-F1	alphafold	PREDICTED	55.36	—

Amino-acid sequence (488 residues)

MFAAGLAPFY ASNFSLWSAA YCSSAGPGGC SFPLDPAAVK KPSFCIADIL HAGVGDLGAA PEGLAGASAA ALTAHLGSVH PHASFQAAAR SPLRPTPVVA PSEVPAGFPQ RLSPLSAAYH HHHPQQQQQQ QQPQQQQPPP PPRAGALQPP ASGTRVVPNP HHSGSAPAPS SKDLKFGIDR ILSAEFDPKV KEGNTLRDLT SLLTGGRPAG VHLSGLQPSA GQFFASLDPI NEASAILSPL NSNPRNSVQH QFQDTFPGPY AVLTKDTMPQ TYKRKRSWSR AVFSNLQRKG LEKRFEIQKY VTKPDRKQLA AMLGLTDAQV KVWFQNRRMK WRHSKEAQAQ KDKDKEAGEK PSGGAPAADG EQDERSPSRS EGEAESESSD SESLDMAPSD TERTEGSERS LHQTTVIKAP VTGALITASS AGSGGSSGGG GNSFSFSSAS SLSSSSTSAG CASSLGGGGA SELLPATQPT ASSAPKSPEP AQGALGCL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards