Caspase-8 (CASP8)

About Caspase-8

Caspase-8 (CASP8) is a protein from Homo sapiens identified by UniProt accession Q14790, 479 residues long. MolForge cross-references it against 0 known binders and 835 disease associations.

Target properties

Protein name	Caspase-8
UniProt accession	Q14790
Gene	CASP8
Organism	Homo sapiens
Length	479 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (835)

Diseases linked to this target (Open Targets).

Autoimmune lymphoproliferative syndrome with recurrent viral infections · score 0.74
autoimmune lymphoproliferative syndrome type 2B · score 0.73
head and neck squamous cell carcinoma · score 0.64
neurodegenerative disease · score 0.54
viral disease · score 0.51
breast adenocarcinoma · score 0.48
cervical squamous cell carcinoma · score 0.43
hepatocellular carcinoma · score 0.42
cutaneous squamous cell carcinoma · score 0.41
nasopharyngeal neoplasm · score 0.41

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14790-F1	alphafold	PREDICTED	81.87	—

Amino-acid sequence (479 residues)

MDFSRNLYDI GEQLDSEDLA SLKFLSLDYI PQRKQEPIKD ALMLFQRLQE KRMLEESNLS FLKELLFRIN RLDLLITYLN TRKEEMEREL QTPGRAQISA YRVMLYQISE EVSRSELRSF KFLLQEEISK CKLDDDMNLL DIFIEMEKRV ILGEGKLDIL KRVCAQINKS LLKIINDYEE FSKERSSSLE GSPDEFSNGE ELCGVMTISD SPREQDSESQ TLDKVYQMKS KPRGYCLIIN NHNFAKAREK VPKLHSIRDR NGTHLDAGAL TTTFEELHFE IKPHDDCTVE QIYEILKIYQ LMDHSNMDCF ICCILSHGDK GIIYGTDGQE APIYELTSQF TGLKCPSLAG KPKVFFIQAC QGDNYQKGIP VETDSEEQPY LEMDLSSPQT RYIPDEADFL LGMATVNNCV SYRNPAEGTW YIQSLCQSLR ERCPRGDDIL TILTEVNYEV SNKDDKKNMG KQMPQPTFTL RKKLVFPSD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards