About Kinesin-like protein KIF22
Kinesin-like protein KIF22 (KIF22) is a protein
from Homo sapiens identified by UniProt accession
Q14807, 665 residues long.
MolForge cross-references it against 0 known binders and
46 disease associations.
Target properties
| Protein name | Kinesin-like protein KIF22 |
|---|
| UniProt accession | Q14807 |
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| Gene | KIF22 |
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| Organism | Homo sapiens |
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| Length | 665 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (46)
Diseases linked to this target (Open Targets).
- spondyloepimetaphyseal dysplasia with multiple dislocations · score 0.76
- genetic disorder · score 0.42
- breast adenocarcinoma · score 0.18
- melanoma · score 0.08
- neoplasm · score 0.08
- urinary bladder carcinoma · score 0.08
- gonorrhea · score 0.07
- Miyoshi myopathy · score 0.07
- benign prostatic hyperplasia · score 0.04
- mean platelet volume · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14807-F1 | alphafold | PREDICTED | 73.96 | — |
Amino-acid sequence (665 residues)
MAAGGSTQQR RREMAAASAA AISGAGRCRL SKIGATRRPP PARVRVAVRL RPFVDGTAGA SDPPCVRGMD SCSLEIANWR NHQETLKYQF DAFYGERSTQ QDIYAGSVQP ILRHLLEGQN ASVLAYGPTG AGKTHTMLGS PEQPGVIPRA LMDLLQLTRE EGAEGRPWAL SVTMSYLEIY QEKVLDLLDP ASGDLVIRED CRGNILIPGL SQKPISSFAD FERHFLPASR NRTVGATRLN QRSSRSHAVL LVKVDQRERL APFRQREGKL YLIDLAGSED NRRTGNKGLR LKESGAINTS LFVLGKVVDA LNQGLPRVPY RDSKLTRLLQ DSLGGSAHSI LIANIAPERR FYLDTVSALN FAARSKEVIN RPFTNESLQP HALGPVKLSQ KELLGPPEAK RARGPEEEEI GSPEPMAAPA SASQKLSPLQ KLSSMDPAML ERLLSLDRLL ASQGSQGAPL LSTPKRERMV LMKTVEEKDL EIERLKTKQK ELEAKMLAQK AEEKENHCPT MLRPLSHRTV TGAKPLKKAV VMPLQLIQEQ AASPNAEIHI LKNKGRKRKL ESLDALEPEE KAEDCWELQI SPELLAHGRQ KILDLLNEGS ARDLRSLQRI GPKKAQLIVG WRELHGPFSQ VEDLERVEGI TGKQMESFLK ANILGLAAGQ RCGAS
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