Myocyte-specific enhancer factor 2D (MEF2D)

About Myocyte-specific enhancer factor 2D

Myocyte-specific enhancer factor 2D (MEF2D) is a protein from Homo sapiens identified by UniProt accession Q14814, 521 residues long. MolForge cross-references it against 0 known binders and 140 disease associations.

Target properties

Protein name	Myocyte-specific enhancer factor 2D
UniProt accession	Q14814
Gene	MEF2D
Organism	Homo sapiens
Length	521 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (140)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.49
BMI-adjusted waist-hip ratio · score 0.32
migraine disorder · score 0.32
diastolic blood pressure · score 0.31
electrocardiography · score 0.30
monocyte count · score 0.30
platelet count · score 0.30
BMI-adjusted waist circumference · score 0.29
TPE interval measurement · score 0.28
platelet crit · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14814-F1	alphafold	PREDICTED	53.76	—

Amino-acid sequence (521 residues)

MGRKKIQIQR ITDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNH SNKLFQYAST DMDKVLLKYT EYNEPHESRT NADIIETLRK KGFNGCDSPE PDGEDSLEQS PLLEDKYRRA SEELDGLFRR YGSTVPAPNF AMPVTVPVSN QSSLQFSNPS GSLVTPSLVT SSLTDPRLLS PQQPALQRNS VSPGLPQRPA SAGAMLGGDL NSANGACPSP VGNGYVSARA SPGLLPVANG NSLNKVIPAK SPPPPTHSTQ LGAPSRKPDL RVITSQAGKG LMHHLTEDHL DLNNAQRLGV SQSTHSLTTP VVSVATPSLL SQGLPFSSMP TAYNTDYQLT SAELSSLPAF SSPGGLSLGN VTAWQQPQQP QQPQQPQPPQ QQPPQPQQPQ PQQPQQPQQP PQQQSHLVPV SLSNLIPGSP LPHVGAALTV TTHPHISIKS EPVSPSRERS PAPPPPAVFP AARPEPGDGL SSPAGGSYET GDRDDGRGDF GPTLGLLRPA PEPEAEGSAV KRMRLDTWTL K

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards