About LIM and SH3 domain protein 1
LIM and SH3 domain protein 1 (LASP1) is a protein
from Homo sapiens identified by UniProt accession
Q14847, 261 residues long.
MolForge cross-references it against 0 known binders and
321 disease associations.
Target properties
| Protein name | LIM and SH3 domain protein 1 |
|---|
| UniProt accession | Q14847 |
|---|
| Gene | LASP1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 261 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (321)
Diseases linked to this target (Open Targets).
- acute myeloid leukemia · score 0.28
- neurodegenerative disease · score 0.24
- serum albumin measurement · score 0.24
- hepatocellular carcinoma · score 0.21
- head and neck squamous cell carcinoma · score 0.21
- esophageal squamous cell carcinoma · score 0.20
- breast carcinoma · score 0.19
- urinary bladder carcinoma · score 0.19
- squamous cell lung carcinoma · score 0.19
- clear cell renal carcinoma · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14847-F1 | alphafold | PREDICTED | 70.45 | — |
Amino-acid sequence (261 residues)
MNPNCARCGK IVYPTEKVNC LDKFWHKACF HCETCKMTLN MKNYKGYEKK PYCNAHYPKQ SFTMVADTPE NLRLKQQSEL QSQVRYKEEF EKNKGKGFSV VADTPELQRI KKTQDQISNI KYHEEFEKSR MGPSGGEGME PERRDSQDGS SYRRPLEQQQ PHHIPTSAPV YQQPQQQPVA QSYGGYKEPA APVSIQRSAP GGGGKRYRAV YDYSAADEDE VSFQDGDTIV NVQQIDDGWM YGTVERTGDT GMLPANYVEA I
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