About Metal regulatory transcription factor 1
Metal regulatory transcription factor 1 (MTF1) is a protein
from Homo sapiens identified by UniProt accession
Q14872, 753 residues long.
MolForge cross-references it against 0 known binders and
103 disease associations.
Target properties
| Protein name | Metal regulatory transcription factor 1 |
|---|
| UniProt accession | Q14872 |
|---|
| Gene | MTF1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 753 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (103)
Diseases linked to this target (Open Targets).
- neuroinflammatory disorder · score 0.37
- pulse pressure measurement · score 0.19
- platelet component distribution width · score 0.14
- vital capacity · score 0.13
- autism spectrum disorder · score 0.12
- blood protein measurement · score 0.12
- Red cell distribution width · score 0.11
- rheumatoid arthritis · score 0.11
- systemic lupus erythematosus · score 0.11
- hemoglobin A1 measurement · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14872-F1 | alphafold | PREDICTED | 49.21 | — |
Amino-acid sequence (753 residues)
MGEHSPDNNI IYFEAEEDEL TPDDKMLRFV DKNGLVPSSS GTVYDRTTVL IEQDPGTLED EDDDGQCGEH LPFLVGGEEG FHLIDHEAMS QGYVQHIISP DQIHLTINPG STPMPRNIEG ATLTLQSECP ETKRKEVKRY QCTFEGCPRT YSTAGNLRTH QKTHRGEYTF VCNQEGCGKA FLTSYSLRIH VRVHTKEKPF ECDVQGCEKA FNTLYRLKAH QRLHTGKTFN CESEGCSKYF TTLSDLRKHI RTHTGEKPFR CDHDGCGKAF AASHHLKTHV RTHTGERPFF CPSNGCEKTF STQYSLKSHM KGHDNKGHSY NALPQHNGSE DTNHSLCLSD LSLLSTDSEL RENSSTTQGQ DLSTISPAII FESMFQNSDD TAIQEDPQQT ASLTESFNGD AESVSDVPPS TGNSASLSLP LVLQPGLSEP PQPLLPASAP SAPPPAPSLG PGSQQAAFGN PPALLQPPEV PVPHSTQFAA NHQEFLPHPQ APQPIVPGLS VVAGASASAA AVASAVAAPA PPQSTTEPLP AMVQTLPLGA NSVLTNNPTI TITPTPNTAI LQSSLVMGEQ NLQWILNGAT SSPQNQEQIQ QASKVEKVFF TTAVPVASSP GSSVQQIGLS VPVIIIKQEE ACQCQCACRD SAKERASSRR KGCSSPPPPE PSPQAPDGPS LQLPAQTFSS APVPGSSSST LPSSCEQSRQ AETPSDPQTE TLSAMDVSEF LSLQSLDTPS NLIPIEALLQ GEEEMGLTSS FSK
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