Ketimine reductase mu-crystallin (CRYM)

About Ketimine reductase mu-crystallin

Ketimine reductase mu-crystallin (CRYM) is a protein from Homo sapiens identified by UniProt accession Q14894, 314 residues long. MolForge cross-references it against 0 known binders and 80 disease associations.

Target properties

Protein name	Ketimine reductase mu-crystallin
UniProt accession	Q14894
Gene	CRYM
Organism	Homo sapiens
Length	314 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (80)

Diseases linked to this target (Open Targets).

autosomal dominant nonsyndromic hearing loss 40 · score 0.63
autosomal dominant nonsyndromic hearing loss · score 0.54
glioblastoma multiforme · score 0.05
central nervous system cancer · score 0.04
cancer · score 0.03
astrocytoma · score 0.03
lung carcinoma · score 0.02
Huntington disease · score 0.02
esophageal squamous cell carcinoma · score 0.02
atypical teratoid rhabdoid tumor · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14894-F1	alphafold	PREDICTED	96.04	—

Amino-acid sequence (314 residues)

MSRVPAFLSA AEVEEHLRSS SLLIPPLETA LANFSSGPEG GVMQPVRTVV PVTKHRGYLG VMPAYSAAED ALTTKLVTFY EDRGITSVVP SHQATVLLFE PSNGTLLAVM DGNVITAKRT AAVSAIATKF LKPPSSEVLC ILGAGVQAYS HYEIFTEQFS FKEVRIWNRT KENAEKFADT VQGEVRVCSS VQEAVAGADV IITVTLATEP ILFGEWVKPG AHINAVGASR PDWRELDDEL MKEAVLYVDS QEAALKESGD VLLSGAEIFA ELGEVIKGVK PAHCEKTTVF KSLGMAVEDT VAAKLIYDSW SSGK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards