About Prostaglandin reductase 1
Prostaglandin reductase 1 (PTGR1) is a protein
from Homo sapiens identified by UniProt accession
Q14914, 329 residues long.
MolForge cross-references it against 0 known binders and
80 disease associations.
Target properties
| Protein name | Prostaglandin reductase 1 |
|---|
| UniProt accession | Q14914 |
|---|
| Gene | PTGR1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 329 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (80)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.35
- protein measurement · score 0.32
- Alzheimer disease · score 0.24
- neurodegenerative disease · score 0.24
- Parkinson disease · score 0.24
- multiple sclerosis · score 0.24
- lysosomal storage disease · score 0.24
- bone measurement · score 0.24
- lymphocyte:monocyte ratio · score 0.18
- liver disease · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14914-F1 | alphafold | PREDICTED | 97.40 | — |
Amino-acid sequence (329 residues)
MVRTKTWTLK KHFVGYPTNS DFELKTAELP PLKNGEVLLE ALFLTVDPYM RVAAKRLKEG DTMMGQQVAK VVESKNVALP KGTIVLASPG WTTHSISDGK DLEKLLTEWP DTIPLSLALG TVGMPGLTAY FGLLEICGVK GGETVMVNAA AGAVGSVVGQ IAKLKGCKVV GAVGSDEKVA YLQKLGFDVV FNYKTVESLE ETLKKASPDG YDCYFDNVGG EFSNTVIGQM KKFGRIAICG AISTYNRTGP LPPGPPPEIV IYQELRMEAF VVYRWQGDAR QKALKDLLKW VLEGKIQYKE YIIEGFENMP AAFMGMLKGD NLGKTIVKA
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