Nuclear factor 1 X-type (NFIX)

About Nuclear factor 1 X-type

Nuclear factor 1 X-type (NFIX) is a protein from Homo sapiens identified by UniProt accession Q14938, 502 residues long. MolForge cross-references it against 0 known binders and 297 disease associations.

Target properties

Protein name	Nuclear factor 1 X-type
UniProt accession	Q14938
Gene	NFIX
Organism	Homo sapiens
Length	502 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (297)

Diseases linked to this target (Open Targets).

Malan overgrowth syndrome · score 0.80
Marshall-Smith syndrome · score 0.79
Sotos syndrome · score 0.57
genetic disorder · score 0.51
cortical surface area measurement · score 0.39
craniosynostosis · score 0.38
neuroimaging measurement · score 0.37
lymphocyte count · score 0.36
brain measurement · score 0.34
cortical thickness · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14938-F1	alphafold	PREDICTED	61.62	—

Amino-acid sequence (502 residues)

MYSPYCLTQD EFHPFIEALL PHVRAFSYTW FNLQARKRKY FKKHEKRMSK DEERAVKDEL LGEKPEIKQK WASRLLAKLR KDIRPEFRED FVLTITGKKP PCCVLSNPDQ KGKIRRIDCL RQADKVWRLD LVMVILFKGI PLESTDGERL YKSPQCSNPG LCVQPHHIGV TIKELDLYLA YFVHTPESGQ SDSSNQQGDA DIKPLPNGHL SFQDCFVTSG VWNVTELVRV SQTPVATASG PNFSLADLES PSYYNINQVT LGRRSITSPP STSTTKRPKS IDDSEMESPV DDVFYPGTGR SPAAGSSQSS GWPNDVDAGP ASLKKSGKLD FCSALSSQGS SPRMAFTHHP LPVLAGVRPG SPRATASALH FPSTSIIQQS SPYFTHPTIR YHHHHGQDSL KEFVQFVCSD GSGQATGQPN GSGQGKVPGS FLLPPPPPVA RPVPLPMPDS KSTSTAPDGA ALTPPSPSFA TTGASSANRF VSIGPRDGNF LNIPQQSQSW FL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards