About Killer cell immunoglobulin-like receptor 2DS3
Killer cell immunoglobulin-like receptor 2DS3 (KIR2DS3) is a protein
from Homo sapiens identified by UniProt accession
Q14952, 304 residues long.
MolForge cross-references it against 0 known binders and
53 disease associations.
Target properties
| Protein name | Killer cell immunoglobulin-like receptor 2DS3 |
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| UniProt accession | Q14952 |
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| Gene | KIR2DS3 |
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| Organism | Homo sapiens |
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| Length | 304 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (53)
Diseases linked to this target (Open Targets).
- cryohydrocytosis · score 0.04
- hepatocellular carcinoma · score 0.02
- neuroblastoma · score 0.02
- acute myeloid leukemia · score 0.02
- lymphoproliferative syndrome · score 0.01
- hepatitis C virus infection · score 0.01
- acute lymphoblastic leukemia · score 0.01
- malaria · score 0.01
- COVID-19 · score 0.01
- myeloid leukemia · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14952-F1 | alphafold | PREDICTED | 80.03 | — |
Amino-acid sequence (304 residues)
MSLMVISMAC VGFFWLQGAW PHEGFRRKPS LLAHPGRLVK SEETVILQCW SDVMFEHFLL HREGTFNDTL RLIGEHIDGV SKANFSIGRM RQDLAGTYRC YGSVPHSPYQ FSAPSDPLDI VITGLYEKPS LSAQPGPTVL AGESVTLSCS SWSSYDMYHL STEGEAHERR FSAGPKVNGT FQADFPLGPA TQGGTYRCFG SFHDSPYEWS KSSDPLLVSV TGNPSNSWPS PTEPSSKTGN PRHLHVLIGT SVVKLPFTIL LFFLLHRWCS DKKNASVMDQ GPAGNRTVNR EDSDEQDHQE VSYA
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