About Killer cell immunoglobulin-like receptor 2DS5
Killer cell immunoglobulin-like receptor 2DS5 (KIR2DS5) is a protein
from Homo sapiens identified by UniProt accession
Q14953, 304 residues long.
MolForge cross-references it against 0 known binders and
56 disease associations.
Target properties
| Protein name | Killer cell immunoglobulin-like receptor 2DS5 |
|---|
| UniProt accession | Q14953 |
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| Gene | KIR2DS5 |
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| Organism | Homo sapiens |
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| Length | 304 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (56)
Diseases linked to this target (Open Targets).
- COVID-19 · score 0.04
- endometriosis · score 0.03
- dengue disease · score 0.02
- viral disease · score 0.02
- ankylosing spondylitis · score 0.02
- hepatitis B virus infection · score 0.02
- chronic hepatitis B virus infection · score 0.02
- malaria · score 0.01
- Rheumatoid arthritis · score 0.01
- chronic myelogenous leukemia · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14953-F1 | alphafold | PREDICTED | 79.46 | — |
Amino-acid sequence (304 residues)
MSLMVISMAC VAFFLLQGAW PHEGFRRKPS LLAHPGPLVK SEETVILQCW SDVMFEHFLL HREGTFNHTL RLIGEHIDGV SKGNFSIGRM TQDLAGTYRC YGSVTHSPYQ LSAPSDPLDI VITGLYEKPS LSAQPGPTVL AGESVTLSCS SRSSYDMYHL SREGEAHERR LPAGPKVNRT FQADFPLDPA THGGTYRCFG SFRDSPYEWS KSSDPLLVSV TGNSSNSWPS PTEPSSETGN PRHLHVLIGT SVVKLPFTIL LFFLLHRWCS NKKNASVMDQ GPAGNRTVNR EDSDEQDHQE VSYA
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