About Killer cell immunoglobulin-like receptor 2DS1
Killer cell immunoglobulin-like receptor 2DS1 (KIR2DS1) is a protein
from Homo sapiens identified by UniProt accession
Q14954, 304 residues long.
MolForge cross-references it against 0 known binders and
71 disease associations.
Target properties
| Protein name | Killer cell immunoglobulin-like receptor 2DS1 |
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| UniProt accession | Q14954 |
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| Gene | KIR2DS1 |
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| Organism | Homo sapiens |
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| Length | 304 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (71)
Diseases linked to this target (Open Targets).
- COVID-19 · score 0.04
- Hodgkins lymphoma · score 0.02
- chronic obstructive pulmonary disease · score 0.02
- ocular toxoplasmosis · score 0.02
- infect · score 0.02
- infection · score 0.02
- psoriasis · score 0.02
- psoriatic arthritis · score 0.01
- malaria · score 0.01
- chronic hepatitis B virus infection · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14954-F1 | alphafold | PREDICTED | 80.90 | — |
Amino-acid sequence (304 residues)
MSLTVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGRLVK SEETVILQCW SDVMFEHFLL HREGMFNDTL RLIGEHHDGV SKANFSISRM KQDLAGTYRC YGSVTHSPYQ LSAPSDPLDI VIIGLYEKPS LSAQPGPTVL AGENVTLSCS SRSSYDMYHL SREGEAHERR LPAGTKVNGT FQANFPLGPA THGGTYRCFG SFRDSPYEWS KSSDPLLVSV TGNPSNSWPS PTEPSSETGN PRHLHVLIGT SVVKIPFTIL LFFLLHRWCS DKKNAAVMDQ EPAGNRTVNS EDSDEQDHQE VSYA
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