About Transmembrane glycoprotein NMB
Transmembrane glycoprotein NMB (GPNMB) is a protein
from Homo sapiens identified by UniProt accession
Q14956, 572 residues long.
MolForge cross-references it against 0 known binders and
411 disease associations.
Target properties
| Protein name | Transmembrane glycoprotein NMB |
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| UniProt accession | Q14956 |
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| Gene | GPNMB |
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| Organism | Homo sapiens |
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| Length | 572 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (411)
Diseases linked to this target (Open Targets).
- familial primary localized cutaneous amyloidosis · score 0.61
- blood protein measurement · score 0.44
- Parkinson disease · score 0.40
- amyloidosis cutis dyschromia · score 0.37
- body height · score 0.30
- electrocardiography · score 0.27
- cerebrospinal fluid biomarker measurement · score 0.27
- lung adenocarcinoma · score 0.23
- transmembrane glycoprotein NMB measurement · score 0.23
- genetic disorder · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14956-F1 | alphafold | PREDICTED | 76.72 | — |
Amino-acid sequence (572 residues)
MECLYYFLGF LLLAARLPLD AAKRFHDVLG NERPSAYMRE HNQLNGWSSD ENDWNEKLYP VWKRGDMRWK NSWKGGRVQA VLTSDSPALV GSNITFAVNL IFPRCQKEDA NGNIVYEKNC RNEAGLSADP YVYNWTAWSE DSDGENGTGQ SHHNVFPDGK PFPHHPGWRR WNFIYVFHTL GQYFQKLGRC SVRVSVNTAN VTLGPQLMEV TVYRRHGRAY VPIAQVKDVY VVTDQIPVFV TMFQKNDRNS SDETFLKDLP IMFDVLIHDP SHFLNYSTIN YKWSFGDNTG LFVSTNHTVN HTYVLNGTFS LNLTVKAAAP GPCPPPPPPP RPSKPTPSLA TTLKSYDSNT PGPAGDNPLE LSRIPDENCQ INRYGHFQAT ITIVEGILEV NIIQMTDVLM PVPWPESSLI DFVVTCQGSI PTEVCTIISD PTCEITQNTV CSPVDVDEMC LLTVRRTFNG SGTYCVNLTL GDDTSLALTS TLISVPDRDP ASPLRMANSA LISVGCLAIF VTVISLLVYK KHKEYNPIEN SPGNVVRSKG LSVFLNRAKA VFFPGNQEKD PLLKNQEFKG VS
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