About Nucleolar and coiled-body phosphoprotein 1
Nucleolar and coiled-body phosphoprotein 1 (NOLC1) is a protein
from Homo sapiens identified by UniProt accession
Q14978, 699 residues long.
MolForge cross-references it against 0 known binders and
57 disease associations.
Target properties
| Protein name | Nucleolar and coiled-body phosphoprotein 1 |
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| UniProt accession | Q14978 |
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| Gene | NOLC1 |
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| Organism | Homo sapiens |
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| Length | 699 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (57)
Diseases linked to this target (Open Targets).
- erythrocyte count · score 0.12
- red blood cell density measurement · score 0.12
- smoking status measurement · score 0.11
- mean corpuscular volume · score 0.10
- mean corpuscular hemoglobin · score 0.09
- mean corpuscular hemoglobin concentration · score 0.09
- hepatocellular carcinoma · score 0.08
- cancer · score 0.08
- mean reticulocyte volume · score 0.08
- triple-negative breast cancer · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14978-F1 | alphafold | PREDICTED | 53.59 | — |
Amino-acid sequence (699 residues)
MADAGIRRVV PSDLYPLVLG FLRDNQLSEV ANKFAKATGA TQQDANASSL LDIYSFWLKS AKVPERKLQA NGPVAKKAKK KASSSDSEDS SEEEEEVQGP PAKKAAVPAK RVGLPPGKAA AKASESSSSE ESSDDDDEED QKKQPVQKGV KPQAKAAKAP PKKAKSSDSD SDSSSEDEPP KNQKPKITPV TVKAQTKAPP KPARAAPKIA NGKAASSSSS SSSSSSSDDS EEEKAAATPK KTVPKKQVVA KAPVKAATTP TRKSSSSEDS SSDEEEEQKK PMKNKPGPYS SVPPPSAPPP KKSLGTQPPK KAVEKQQPVE SSEDSSDESD SSSEEEKKPP TKAVVSKATT KPPPAKKAAE SSSDSSDSDS SEDDEAPSKP AGTTKNSSNK PAVTTKSPAV KPAAAPKQPV GGGQKLLTRK ADSSSSEEES SSSEEEKTKK MVATTKPKAT AKAALSLPAK QAPQGSRDSS SDSDSSSSEE EEEKTSKSAV KKKPQKVAGG AAPSKPASAK KGKAESSNSS SSDDSSEEEE EKLKGKGSPR PQAPKANGTS ALTAQNGKAA KNSEEEEEEK KKAAVVVSKS GSLKKRKQNE AAKEAETPQA KKIKLQTPNT FPKRKKGEKR ASSPFRRVRE EEIEVDSRVA DNSFDAKRGA AGDWGERANQ VLKFTKGKSF RHEKTKKKRG SYRGGSISVQ VNSIKFDSE
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