Opioid-binding protein/cell adhesion molecule (OPCML)

About Opioid-binding protein/cell adhesion molecule

Opioid-binding protein/cell adhesion molecule (OPCML) is a protein from Homo sapiens identified by UniProt accession Q14982, 345 residues long. MolForge cross-references it against 0 known binders and 113 disease associations.

Target properties

Protein name	Opioid-binding protein/cell adhesion molecule
UniProt accession	Q14982
Gene	OPCML
Organism	Homo sapiens
Length	345 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (113)

Diseases linked to this target (Open Targets).

body mass index · score 0.46
ovarian cancer · score 0.45
mathematical ability · score 0.41
self reported educational attainment · score 0.40
Visual impairment · score 0.37
ovarian carcinoma · score 0.37
neurofibrillary tangles measurement · score 0.36
PHF-tau measurement · score 0.34
Arthropathy · score 0.34
cognitive function measurement · score 0.33

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14982-F1	alphafold	PREDICTED	83.43	—

Amino-acid sequence (345 residues)

MGVCGYLFLP WKCLVVVSLR LLFLVPTGVP VRSGDATFPK AMDNVTVRQG ESATLRCTID DRVTRVAWLN RSTILYAGND KWSIDPRVII LVNTPTQYSI MIQNVDVYDE GPYTCSVQTD NHPKTSRVHL IVQVPPQIMN ISSDITVNEG SSVTLLCLAI GRPEPTVTWR HLSVKEGQGF VSEDEYLEIS DIKRDQSGEY ECSALNDVAA PDVRKVKITV NYPPYISKAK NTGVSVGQKG ILSCEASAVP MAEFQWFKEE TRLATGLDGM RIENKGRMST LTFFNVSEKD YGNYTCVATN KLGNTNASIT LYGPGAVIDG VNSASRALAC LWLSGTLLAH FFIKF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards