About Nuclear receptor subfamily 1 group D member 2
Nuclear receptor subfamily 1 group D member 2 (NR1D2) is a protein
from Homo sapiens identified by UniProt accession
Q14995, 579 residues long.
MolForge cross-references it against 0 known binders and
181 disease associations.
Target properties
| Protein name | Nuclear receptor subfamily 1 group D member 2 |
|---|
| UniProt accession | Q14995 |
|---|
| Gene | NR1D2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 579 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (181)
Diseases linked to this target (Open Targets).
- intelligence · score 0.39
- self reported educational attainment · score 0.33
- cognitive function measurement · score 0.33
- mathematical ability · score 0.32
- appendicular lean mass · score 0.30
- familial atrioventricular septal defect · score 0.26
- hepatocyte growth factor measurement · score 0.23
- verbal-numerical reasoning measurement · score 0.19
- smoking status measurement · score 0.15
- antisocial behaviour measurement · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14995-F1 | alphafold | PREDICTED | 64.78 | — |
Amino-acid sequence (579 residues)
MEVNAGGVIA YISSSSSASS PASCHSEGSE NSFQSSSSSV PSSPNSSNSD TNGNPKNGDL ANIEGILKND RIDCSMKTSK SSAPGMTKSH SGVTKFSGMV LLCKVCGDVA SGFHYGVHAC EGCKGFFRRS IQQNIQYKKC LKNENCSIMR MNRNRCQQCR FKKCLSVGMS RDAVRFGRIP KREKQRMLIE MQSAMKTMMN SQFSGHLQND TLVEHHEQTA LPAQEQLRPK PQLEQENIKS SSPPSSDFAK EEVIGMVTRA HKDTFMYNQE QQENSAESMQ PQRGERIPKN MEQYNLNHDH CGNGLSSHFP CSESQQHLNG QFKGRNIMHY PNGHAICIAN GHCMNFSNAY TQRVCDRVPI DGFSQNENKN SYLCNTGGRM HLVCPMSKSP YVDPHKSGHE IWEEFSMSFT PAVKEVVEFA KRIPGFRDLS QHDQVNLLKA GTFEVLMVRF ASLFDAKERT VTFLSGKKYS VDDLHSMGAG DLLNSMFEFS EKLNALQLSD EEMSLFTAVV LVSADRSGIE NVNSVEALQE TLIRALRTLI MKNHPNEASI FTKLLLKLPD LRSLNNMHSE ELLAFKVHP
Explore Nuclear receptor subfamily 1 group D member 2 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets